Untranslated Gene Regions and Other Non-Coding Elements: Regulation of Eukaryotic Gene Expression

ISBN-13: 9783034806787 / Angielski / Miękka / 2013 / 56 str.

Lucy W. Barrett; Sue Fletcher; Steve D. Wilton

Opis

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA," it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Spis treści

Introduction.- Promoter.- 5’ Untranslated Region.- Structure.- Intronic Regions.- 3’ Untranslated Region.- Non-coding RNAs.- Conclusion.