Trp Channels as Therapeutic Targets: From Basic Science to Clinical Use

ISBN-13: 9780124200241 / Angielski / Twarda / 2015 / 536 str.

Szallasi, Arpad

Opis

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

• Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials
• Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more
• Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them

Recenzje

"...provides a useful meta-review of a field in which numerous journal reviews have been published, few of which approach the big picture and detailed historical assessment of drug development and testing found here. Score: 84 - 3 Stars" --Doody's

Spis treści

1. Introduction
2. Hereditary TRP Channelopathies
3. Changes in TRP Channel Expression in Acquired Diseases
4. TRP Gene Polymorphism and Disease Risk
5. Topical Capsaicin for Pain Relief
6. TRPV1 agonist cytotoxicity for chronic pain relief
7. Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders
8. Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents
9. TRPA1 Antagonists for Pain Relief
10. TRPA Antagonistsas Therapeutic Strategies to Reduce the Symptoms and Pathophysiology of Respiratory Disorders
11. TRPV3 Receptors as Drug Targets: A Decade of Learning
12. Small Molecule Agonists and Antagonists of TRPV4
13. Potential Therapeutic Applications for TRPV4 Antagonists in Lung Disease
14. TRPM8 as a Target for Analgesia
15. TRP Channels: Connectivity to Cerebral Vascular Disease
16. TRP Channels' Key Role in the Transduction of Itch
17. Role of TRP Channels in Skin Diseases
18. TRP Channels in Obesity/Metabolic Syndrome
19. TRP Channels in Diabetes
20. TRP Channels and Ca²+ Entry in Cardiac Disease
21. The Contribution of TRP Channels to Pathophysiological Regulation of the Gastrointestinal Tract
22. Cancer: Oncogenic and Anti-Oncogenic TRP Channels as Biomarkers and Therapeutic Targets
23. TRP Channels in the Brain
24. A: Mucolipidosis and TRPML Channels
24 B: TRPML1-dependent Processes as the Therapeutic Targets
25. TRPs in respiratory disorders: opportunities beyond TRPA1
26. Concluding Remarks