Trafficking of Gpcrs: Volume 132

ISBN-13: 9780128029398 / Angielski / Twarda / 2015 / 328 str.

Wu, Guangyu

Opis

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms.

• Written by future leaders in the pain field
• Covers a wide range of targets
• Contains provocative ideas about GPCR trafficking

Spis treści

1. Arrestins: Critical Players in Trafficking of Many GPCRsVsevolod V. Gurevich and Eugenia V. Gurevich
2. Regulation of GPCR Trafficking by UbiquitinJustine E. Kennedy and Adriano Marchese
3. Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and MechanismsIna Nemet, Philip Ropelewski and Yoshikazu Imanishi
4. Intracellular Trafficking of Neuropeptide Y ReceptorsKarin Mörl and Annette G. Beck-Sickinger
5. Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and InternalizationMichèle Darmon, Sana Al Awabdh , Michel-Boris Emerit and Justine Masson
6. Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of Interacting ProteinsKausik Ray
7. Trafficking of ß Adrenergic Receptors: Implications in Intracellular Receptor SignalingQin Fu and Yang K. Xiang
8. Post-endocytic sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.Shanna L. Bowman and Manojkumar A. Puthenveedu
9. a2 Adrenergic Receptor Trafficking as a Therapeutic Target in Antidepressant Drug ActionChristopher Cottingham, Craig J. Ferryman and Qin Wang
10. Regulation of a2B-Adrenerigc Receptor Export Trafficking by Specific Motifs Guangyu Wu, Jason E. Davis and Maoxiang Zhang
11. Temperature-Sensitive Intracellular Traffic of ?2c-Adrenergic ReceptorCatalin M. Filipeanu
12. N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking and Signal TransductionClaudia Rutz, Wolfgang Klein and Ralf Schülein
13. Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs Brent Young, Jaime Wertman and Denis J. Dupré

O autorze

Dr. Guangyu Wu, the editor of this book, is a professor in the Department of Pharmacology and Toxicology at the Medical College of Georgia, Georgia Regents University. The long term goal of Dr. Wu's research effort is to define the molecular mechanisms underlying the intracellular trafficking and signal propagation of GPCRs. Dr. Wu's research at the earlier stages, as a graduate student and a post-doctoral fellow, was mainly on the GPCR pharmacology and signal transduction pathways. Since starting his own laboratory in the Department of Pharmacology at Louisiana State University Health Sciences Center New Orleans, Dr. Wu has focused his research on the regulation of GPCR export from the endoplasmic reticulum through the Golgi apparatus to the cell surface through studying the function of well-defined transport machinery at different intracellular organelles and defining specific motifs embedded within the receptors that direct receptor export from the ER/Golgi or cell surface transport.