Toxicology of Glutathione Transferases

ISBN-13: 9780367390532 / Angielski / Miękka / 2019 / 375 str.

Yogesh C. Awasthi

Opis

The most important enzymes protecting human and other organisms from potentially toxic chemicals, Glutathione S-transferases (GSTs) are central to basic mechanisms such as stress response and physiological functions including protection against lipid peroxidation. This book describes the role of GST in toxicology, focusing on their pharmacologic and physiological roles and their relevance to biological toxicology. It covers structure and function, gene regulation, and these enzymes’ involvement in signal transduction. Reflecting current trends in this expanding research area, Toxicology of Glutathione Transferases is the only source that details the methods of GST research.

Spis treści

Preface.Ligandin and Glutathione S-Transferases; Historical Milestones. Families of Glutathione Transferases.Mammalian Glutathione S-Transferase Genes: Structure and Regulation. Combinatorial Protein Chemistry In Three Dimensions: A Paradigm For The Evolution Of Glutathione Transferases With Novel Activities. Substrates and Reaction Mechanisms of GSTs. Specificity of Glutathione S-Transferases in the Glutathione Conjugation of Carcinogenic Diol Epoxides. GST Polymorphism: Where To Now? Clinical Applications and Functional Analysis. Glutathione and Glutathione S-Transferases as Targets for Anticancer Drug Development.Physiological Substrates of Glutathione S-Transferases. Glutathione S-transferases as modulators of signal transduction. Glutathione-conjugate transport and Stress-Response Signaling: Role of RLIP76. Glutathione-S-Transferases and Oxidative Injury of Cardiovascular Tissues. Mitochondrial Glutathione S-Transferase Pool in Health and Disease. Activation of Microsomal Glutathione Transferase ¹ in Toxicology. Glutathione S-transferase Isozyme Composition of Human Tissues. Enzymology of glutathione S-transferases: Laboratory Methods.

O autorze

Yogesh C. Awasthi