Toxicology and Risk Assessment

ISBN-13: 9789814613385 / Angielski / Twarda / 2015 / 1426 str.

Anna M. Fan; George Alexeeff; Elaine Khan

Opis

This work introduces the fundamental principles and current concepts of toxicology and risk assessment, offering comprehensive discussions on clinical testing, risk assessment of chemicals and hazardous materials, the application of animal data to human health risk assessment, mathematical models, statistical approaches, environmental laws, information resources and risk management.

Spis treści

Principles and Approaches for Human Health Risk Assessment of Environmental Contaminants. Dose-Response Assessment: Significance in Risk Assessment. Recent Advances in Cancer Estimation. Consideration of Infants and Children in Risk Assessment. Role of Epidemiology in Drinking Water Risk Assessment. Approaches to Using Structure Activity Relationship (SAR) Analysis with Mechanistic Considerations to Assess Carcinogenic Hazard/Risk Potential of Chemical Substances. The Application of PBPK Modeling, Bayesian Approach, and the Utilization of Markov Chain Monte Carlo Simulation in Risk Assessment. Risk Assessment of Trichloroethylene. Fumigants: Toxicology and Development of Acute Reference Concentrations for Methyl Iodide, Methyl Bromide and Chloropicrin. Cholinesterase Inhibiting Pesticides: Toxicity, Mechanisms, and Implications for Risk Assessment. Mode of Action Toxicity Pathways Demonstrate Developmental Male Reproductive Risk from Endosulfan. Evidence on the Carcinogenicity of Butyl Benzyl Phthalate (BBP) and Possible Mechanisms of Action. The Cell and Molecular Biology of Nickel-Induced Cell Transformation and Carcinogenesis. Asbestos. Nanoparticles and Human Health: Physicochemical Considerations. Nanomaterials: Feasibility and Challenges for Human Health Risk Assessment. Nanotechnology: Emerging Research and Implications for Health and Policy. Emergency Response: Application of Toxicology and Risk Assessment. Toxicology Application in Drug Development. Application of Toxicology in Food Safety Assessment. Chemical Toxicity Testing and Risk Assessment Practice in China. Federal-State Toxicology and Risk Analysis Committee (FSTRAC): Communication and Coordination of Toxicology and Risk Assessment of Environmental Contaminants Communication and Coordination of Toxicological Issues and Risk Analysis Activities Relating to Environmental Contaminants. Challenges and Opportunities for Older Adults. Occupational Health and Safety Risks for the Aging Worker. Health Implications of Chemicals and Pharmaceutics in an Aging Population. Water Consumption Data for Derivation of Drinking Water Ingestion Rates for Different Age Groups. Food Consumption Rates for Estimating Exposures to Chemicals in Food. Risk Assessment and Critical Thinking. Risk Assessment of Chemicals in Drinking Water: Current Concepts and Methodology, Accomplishments, and Future Perspectives.