Tocotrienols: Vitamin E Beyond Tocopherols

ISBN-13: 9781439884416 / Angielski / Twarda / 2012 / 400 str.

Barrie Tan; Ronald Ross Watson; Ed. Victor R. Preedy

Opis

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters. Highlights

• Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
• Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
• Tocopherol interference with tocotrienol functions
• All new chapters and many new contributors

Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.Dr. Tan discusses the benefits of tocotrienol in a YouTube video.

Spis treści

Tocotrienols in Plants: Occurrence, Biosynthesis, and Function. Safety of Unsaturated Vitamin E Tocotrienols and Their Isomers. Bioavailability and Metabolism of Tocotrienols. Bioavailability of Tocotrienols and Interference of Their Bioavailability by α-Tocopherol Supplementation. Alpha-Tocopherol: A Detriment to Tocotrienol Benefits. Antiangiogenic Effects of Tocotrienol. Mechanism of Delta-Tocotrienol on Colorectal Cancer. Targeted Prostate Cancer Chemoprevention Trial with Tocotrienols. δ-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast Cancer. Mevalonate-Suppressive Tocotrienols for Cancer Chemoprevention and Adjuvant Therapy. Potential of Tocotrienols in Lung Cancer. Tocotrienols and Atherosclerosis: Potential in Cardioprotection. Tocotrienols: Viable Options for Managing Metabolic Diseases. Tocotrienols as Possible Treatments for Obesity. Tocotrienols, Inflammation, and Cancer: How Are They Linked? 1-Modulating NF-κB Activity by Tocotrienols. Antioxidant Action of Tocotrienols. Tocotrienol in Human Pancreatic Cancer. Tocotrienols in the Treatment of Dyslipidemia. Tocotrienols and Vascular Effects. Prolongevity Effects of Tocotrienols: Trials in Caenorhabditis elegans. Anti-Tyrosinase Activity of Tocotrienol in Skin Blemishes. Tocotrienols and Bone Health. Tocotrienol and Physiology of Reproduction. Tocotrienol and Tocopherol in Stress-Induced Gastric Mucosal Injury. Structural Modification of Tocotrienols to Improve Bioavailability.