Therapeutic Applications of Quadruplex Nucleic Acids

ISBN-13: 9780128103722 / Angielski / Miękka / 2016 / 208 str.

Stephen Neidle

Opis

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.

Spis treści

1. Intro - history and milestones2. Fundamentals of DNA and RNA quadruplex structure and stability3. Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance4. Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents5. Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit6. Quadruplex ligands - chemistry and design - selectivity and assays7. Quadruplex ligands - basic biology and assays indirect and direct8. Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development9. Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding10. Future directions and conclusions