The Translational Apparatus: Structure, Function, Regulation, Evolution

ISBN-13: 9781461360216 / Angielski / Miękka / 2013 / 746 str.

K. H. Nierhaus; F. Franceschi; A. R. Subramanian

Opis

The conference entitled "The Translational Apparatus" was held in Berlin from October 31 to November 5, 1992, in honorem et memoriam of H. G. Wittmann. The presentations of the rewarding, enjoyable and scientifically exciting week in Berlin were a fitting appreciation of this great man, and all participants and speakers contributed to the success of the meeting. The second reason for holding the Berlin meeting was to convene a group of scientists for a state-of-the-art presentation on ribosomes and related subjects; the outcome is this book. We have broadened the spectrum of topics to cover activities preceding and following pure ribosomal functions, such as "Synthetases" and "Protein Sorting," respectively, and we took the liberty of ordering the contributions in a way which does not always reflect the order of speakers. We are grateful to the authors who patiently tolerated our organization and our regulations for manuscripts. K.H. Nierhaus F. Franceschi A.R. Subramanian v CONTENTS I. tRNA and Aminoaeyl-tRNA Synthetases 1. The Crystal Structure of SeryI-tRNA Synthetase and its Complexes with A TP and tRNASer................................................................................................................. 1 S. Cusack, C. Berthet-Colominas, V. Biou, F. Borel, M. Fujinaga, M. Hartlein, I.

Spis treści

tRNA and AminoacyltRNA Synthetases: Charging of RNA Microhelices and Decoding Genetic Information; P. Schimmel. rRNA and mRNA: Regulation, Processing, and Assembly: Genetic Approaches to the Study of Eukaryotic Ribosomes; J.R. Warner, et al. Translational Initiation and Termination: Mechanisms of Translational Initiation and Repression in Prokaryotes; D.E. Draper. The Elongation Process: Sites, Factors, Nascent Chain: The Allosteric ThreeSite Model and the Mechanism of Action of Both Elongation Factors EFTu and EFG; K.H. Nierhaus, et al. Accuracy in Translation: Mutants of tRNA, Ribosomes, and mRNA Affecting Frameshifting, Hopping, or Stop Codon Read-Through; J.F. Atkins, et al. Quaternary Structure, Functional Centers, and Domains in the Ribosome. Translation in Cell Organelles. The Translational Apparatus and Evolution. 64 additional articles. Index.