The Role of Neurotransmitters in Brain Injury

ISBN-13: 9781461365280 / Angielski / Miękka / 2012 / 378 str.

W. D. Dietrich; M. y. T. Globus

Opis

Neuroscientists from various disciplines have given extraordinary attention to the role of neurotransmitters in the field of neuronal injury. This volume summarizes the original oral and poster contributions which were presented at the symposium, "The Role of Neurotransmitters in Brain Injury," in Key West, Florida, between June 7-9, 1991. This symposium was the official Satellite of Brain-91, the Fifteenth International Symposium on Cerebral Blood Flow and Metabolism, held in Miami the previous week. The two principal goals of the Key West satellite meeting were to document recent progress and, more importantly, to explore future directions for investigative studies of the role of neurotransmitters in brain injury. To achieve these goals we assembled participants from diverse scientific fields and specialties who brought their collective expertise to discussions on the importance of neurotransmitters in neuronal and vascular injury following brain ischemia, trauma, and epilepsy. Their contributions are reflected in this volume. An important section of this volume is devoted to the role of glutamate and glutamatergic receptors in the development of ischemic neuronal damage. Topics covered include the mechanisms of glutamate and other excitatory amino acids, and the role of underlying injury-induced release different glutamatergic receptors in brain injury, including the NMDA and the non-NMDA receptors. The involvement of other neurotransmitters in the process of ischemic brain injury is well established.

Spis treści

InjuryInduced Release of Excitatory Amino Acids: Excitatory Amino Acid Release after Focal Cerebral Ischemia (R. Bullock et al.). The Role of Glutamatergic Receptor in Brain Injury: Dizocilpine (MK801) in Cerebral Ischemia (R.N. Auer). The Role of Monoamines in Brain Injury: Role of Nigrostriatal Projections in the Vulnerability of the Striatum (A. Buisson et al.). The Role of Steroids, Adenosine, GABA, and Acetylcholine in Brain Injury: The Role of Glucocorticoids in Ischemic Cell Death (J.N. Davis et al.). Intracellular Messengers and Brain Injury: Changes in Gene Expression after Transient Ischemia as Potential Markers for Excitotoxic Pathology (T.S. Nowak et al.). Blood Brain Barrier in Brain Injury: Ultrastructural Studies of Endothelium in NMDAInduced Excitotoxicity (S. Nag). Neurotransmitter Modulation of Cerebral Blood Flow and Metabolism. Neurotransmitters and Free Radical Mediated Injury. 51 additional articles. Index.