The Reticuloendothelial System in Health and Disease: Immunologic and Pathologic Aspects

ISBN-13: 9781468433029 / Angielski / Miękka / 2012 / 476 str.

Friedman, Herman

Opis

An extraordinary development of the knowledge, concepts and biomedical applications has occurred during the past two decades in the biological sciences, including the Reticuloendothelial Sys- tem (RES). For example, it is now widely recognized that distinct classes of cells are involved in the recognition of "exogenous" invaders of the body such as microorganisms and other foreign an- tigens, as well as of "endogenous" parasites represented by trans- formed neoplastic cells and altered "self" antigens. Prominent among cell populations involved in such recognition of antigens and subsequent immune responses are those constituting the RES. In recent years, there has been much discussion and indeed contro- versy as to what constitutes such a system and even whether the term "RES" is appropriate. Some investigators feel that the phago- cytes are the most important cells of the RES as they playa major role in the defense mechanism of the host. Mononuclear phagocytes include tissue macrophages s well as circulating monocytes and their precursors. Although phagocytosis is a major functional ac- tivity, it is only one of their several functions. The important role of phagocytes and other mononuclear cells in antibody forma- tion, cell-mediated immunity, specific and non-specific resistance to microorganisms and tumor cells, as well as homeostatic adjust- ments in general has become the focus of attention for many inves- tigators.

Spis treści

of Part B.- Section 1 Immunologic and Pathologic Aspects of the RES.- The Role of the T Cell in the Immune Response.- Killer Cell Mechanisms.- Immunogenetics.- T Cell Subsets.- Chronic Allotype Suppression.- References.- Immunological Tolerance: New Parameters for B-Cell Tolerance In vitro.- Summary and Conclusion.- References.- RES Blockade: Effects on Immunity and Tolerance.- General Methods and Experimental Procedures.- Experimental Results and Conclusions.- Discussion and Conclusions.- Summary.- Acknowledgements.- References.- Modulation of the Expression of a Secondary IgG Antihapten Response In vitro.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- External Control of a Shift in Antibody Synthesis.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Effect of Antigen on Localization of Immunologically Specific B Cells.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Localization of Immunoglobulins in Germinal Centers of Human Tonsils.- Materials and Methods.- Results.- Discussion.- References.- ?2-Microglobulin of Lymphocytes.- Acknowledgements.- References.- Effect of Reserpine on Serum Hemolysin Response in Mice.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- The Preparation of an Antiserum Against Human Monocytes.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Lymphocyte Subpopulations: Analysis of T-Cell Rosette Characters.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Section 2 The RES in Immunopathology and Autoimmunity.- Immunopathology of the Nervous System.- References.- Altered Neutrophil Function Induced by Serum from Patients with Systemic Lupus Erythematosus.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Primary Immunodeficiency Diseases.- References 17.- Malnutrition, the Thymolymphatic System and Immunocompetence.- Materials and Methods.- Results.- Discussion.- References.- Antigen and Immune Complex Induced Suppression of Delayed Hypersensitivity.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Plasma Cell Surface Antigen in Thermal Burns, Carcinogenesis and Primary Immunodeficiencies.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Spontaneous Autoimmune Thyroiditis in the BUF Rat.- Summary.- Acknowledgements.- References.- Antibody-Dependent Cell-Mediated Cytotoxicity to Target Cells Infected with Herpes Simplex Virus.- Materials and Methods.- Results and Discussion.- Acknowledgements.- References.- Section 3 The RES in Transplantation Immunology.- Immunogenetic Aspects of Allotransplantation.- Conclusions.- Acknowledgements.- References.- Alloantibodies in Relation to the Rejection of Skin Allografts in the Mouse.- Acknowledgements.- References.- Immunosuppression of Rosette-Forming Cells.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Biological and Pathological Characteristics in Mouse Lines with Large Differences in Leukocyte Counts.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Cell-Mediated Immunity in Long Term Transplant Patients.- Materials and Methods.- Results.- Discussion.- References.- Section 4 The RES in Tumor Immunology.- The Interactions of a Leukemia Virus with Cells of the RES.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Neoplastic Invasion and Metastasis Within the Lymphoreticular System.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Adoptive Immunotherapy of Spontaneous Leukemia-Lymphoma in AKR Mice.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Surface Morphology of Leukemia Virus-Infected Lymphoid Cells.- Materials and Methods.- Results.- Discussion.- References.- Host Immunoreactivity to CSA, a Tissue-Specific Antigen of Normal and Neoplastic Human Intestine.- Materials and Methods.- Results and Discussion.- Acknowledgements.- References.- Tissue Polypeptide Antigen (TPA) in Human Cancer Defense Responses.- Materials and Methods.- Results.- Clinical Studies.- Discussion.- Acknowledgements.- References.- Age-Dependent Regression of M-MSV Tumors in CBA/H Mice: Requirement for a Macrophage-Adherent Cell Population.- Materials and Methods.- Results and Discussion.- Acknowledgements.- References.- Host Protection by Cell-Mediated and by Humoral Immunity in Malignancy.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- In vitro Tumor Growth Inhibition by Syngeneic Lymphocytes and/or Macrophages.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Inhibition of Growth and Dissemination of Shay Myelogenous Leukemic Tumor in Rats by Glucan and Glucan Activated Macrophages.- Results.- Discussion.- Acknowledgement.- References.- Macrophage Participation in a Spontaneously Regressing Syngeneic Tumor.- Tumor Development in the Syngeneic Host.- In vitro Responses of Spleen Cells from Tumor-Bearing Animals.- Suppressor Activity in Spleens of Progressor Phase Animals.- Dual Role for the Macrophage?.- Acknowledgement.- References.- Interaction of Macrophages with Tumor Cells.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Workshop.- RES — Radiobiology and Environmental Factors.- Radiation Effects on Cells of the RES.- References.- Physiologic Mechanisms in Radiation Resistance.- References.- Immunologic Aspects of Malnutrition.- References.- Post-Congress Workshop Summary.- Methods in Basic Laboratory Immunology.- List of Participants.