The Molecular Immunology of Complex Carbohydrates-3

ISBN-13: 9781489979049 / Angielski / Miękka / 2016 / 809 str.

Albert M Wu

Opis

Based on the third symposium on "Molecular Immunology of Complex Carbohydrates," this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences.

This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.

Spis treści

Part 1: Introduction to Glyco-Experiences

Chp 1: Serendipity in Scientific Discoveries: Some Examples in Glycosciences

Chp 2: My 30 Years Devotion to the N-linked Oligosaccharide Structures

 

Part 2: Blood group ABH/Le-related antigens

Chp 3: Human Blood Group ABH/Ii, Lea, b, x, y and Sialyl Lea, x Glycotopes, Internal Structures and Immunochemical Roles of Human Ovarian Cyst Glycoproteins

Chp 4: Lewis Glyco-Epitopes: Structure, Biosynthesis and Functions

Chp 5: An Unique Endo--Galactosidase that Cleaves Both Blood Group A and B Glycotopes

 

Part 3: Lectins     

Chp 6: Recognition Intensities of Mammalian Structural Units, Ligand Clusters and Polyvalency in the Lectin-Glycan Interaction Processes

Chp 7: Adhesion/Growth-Regulatory Galectins: Insights into their Ligand Selectivity Using Natural Glycoproteins and Glycotopes

Chp 8: Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens

Chp 9: The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL and CV-IIL) – Interactions with Diverse Animal Cells and Glycoproteins

Chp 10:       On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica

Chp 11:       Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: Effects of Choline, Trehalose and Ethanol

Chp 12:       Non-Carbohydrate Mediated Interaction of Lectins with Plant Proteins

Chp 13:       Novel Concepts about the Role of Lectins in the Plant Cell

 

Part 4: Structures and Functions of Glycolipids

Chp 14:       Role of Gangliosides and of Plasma Membrane Associated Sialidase in the Process of Cell Membrane Organization

Chp 15:       9-O-Acetyl GD3 in Lymphoid and Erythroid Cells

Chp 16:       GM3 Up-Regulation of Matrix Metalloproteinase-9 (MMP-9) Possibly through PI3K, AKT, RICTOR, RhoGDI-2 and TNF-α Pathways in Mouse Melanoma B16 Cells

Chp 17:       Pathological Roles of Ganglioside Mimicry in Guillain-Barré Syndrome and Related Neuropathies

Chp 18:       Structure and Function of Glycolipids in Thermophilic Bacteria

Chp 19:       Lipooligosaccharides (LOSs) of Neisseria Species: Similarity between N. Polysaccharea and N. Meningitidis LOSs

 

Part 5: Structures and Functions of Complex Carbohydrates    

Chp 20:       Roles for N- and O-Glycans in Early Mouse Development

Chp 21:       Glycobiology in the Field of Gerontology (Glycogerontology)

Chp 22:       Galectins in Regulation of Apoptosis

Chp 23:       Avian and Human Influenza Virus Receptors and their Distribution

Chp 24:       Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis

Chp 25:       Mucin O-Glycan Branching Enzymes: Structure, Function and Gene Regulation

Chp 26:       Studying the Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes

Chp 27:       Docking of Chitin Oligomers and Nod Factors on LysM Lectin Domains of the LysM-RLK Receptors as a First Recognition Step for the Establishment of the Medicago truncatula-Rhizobium Symbiosis

 

Part 6: Glyco-Immunology  

Chp 28:       O-Acetylated Sialic Acids and their Role in Immune Defence

Chp 29:       Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs – Involvement in Traffic and Homing of Human Memory T- and B- Lymphocytes

Chp 30:       Diversity of Natural Anti--Galactosyl Antibodies in Human Serum

Chp 31:       Prospective Highlights of Serum Glycoprotein Profiles in Spontaneous Tolerance after Liver Allograft Transplantation

 

Part 7: Glycobiology of Cancer   

Chp 32:       Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands

Chp 33:       Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by L-PPMP and cis-Platin

Chp 34:       Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells. Consequences on Tumor-Host Interactions

Chp 35:       Human KDN (Deaminated Neuraminic Acid) and its Elevated Expression in Cancer Cells – Mechanism and Significance

Chp 36:       Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N-Acyl Sialic Acid Precursor Treatment

 

Part 8: Glyco-Applications

Chp 37:       Synthesis of Hemagglutinin-Binding Trisaccharides

Chp 38:       Fabrication and Applications of Glyco-Nanomaterials

Chp 39:       Glycan Arrays to Decipher the Specificity of Plant Lectins

Chp 40:       Targeting C-Type Lectin for the Treatment of Flavivirus Infections

 

APPENDIX     

INDEX

O autorze

Dr. Wu has been studying on lectin–glycan interactions for more than 35 years, especially the recognition factors of lectins. He is the senior editor of the Molecular Immunology of Complex Carbohydrates 1 and 2 (Adv. Exp. Med. Biol. 228 and 491). Lectin recognition index is his ongoing project.

Blurb

Based on the proceedings of the third international symposium on “Molecular Immunology of Complex Carbohydrates,” this text is the latest in a series dedicated to glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences.

Section I of the book pays tribute to three pioneers in the field—Walter T.J. Morgan, Elvin A. Kabat and especially Winifred M. Watkins; it presents advanced concepts concerning the structure and functions of Blood group ABH/Le-related antigens, offering a comprehensive review on human blood group ABH/Ii, Le^a,b,x,y and siayl Le^a,x glycotopes of human ovarian cyst glycoproteins. Section II covers the interactions of plant, bacterial and animal lectins with carbohydrates and proteins. Section III describes the structures and functions of gangliosides and microbial glycolipids. Section IV covers the physiological roles of other clycocunjugates in humans, animals, sponges and bacteria as well as aging-related alterations of glycosylation profile in humans. Section V discusses the role of carbohydrates as antigens and regulators of the immune response. Section VI addresses some aspects of the glycobiology of cancer. And section VII details new methodologies in glycol-synthesis and lectin-carbohydrate binding assays and strategies for treatment as crucial applications.