The Gut as a Model in Cell and Molecular Biology

ISBN-13: 9780792387268 / Angielski / Twarda / 1997 / 324 str.

F. Halter; N. A. Wright; D. Winton

Opis

There are many separate groups working in gut biology, and they feel that the gut is an excellent model for investigating general problems in differentiation, growth control, stem cell biology, and regeneration and adaptive responses. There is a pressing need to define the objectives of the next 5 to 10 years, and the meeting, Part III of the Gastroenterology Symposia Freiburg 1996 (Falk Symposium No. 94), held in Freiburg, Germany, October 25-26, brought together some of these groups with a view to identifying areas which are not being utilized and need to be exploited, such as transgenic and knockout approaches, retrovirus delivery systems, and model cell/tissue systems.
The main themes of the book are gastrointestinal development and differentiation, gut stem cell biology, and the control of gut growth in normal and abnormal situations. Basic research findings are related to clinical situations, and the book will appeal not only to gut cell and molecular biologists, but also to gastroenterologists interested in the potential applications of these subject areas.

Spis treści

Preface. Section I: Stem Cells. 1. Intestinal Stem Cells and Clonality; D.J. Winton. 2. The Stem Cells Niche Hypothesis, Mutation and Neoplasia; E.D. Williams. 3. Mutant Stem Cells; M. Bjerknes, H. Cheng. 4. Towards Gene Correction for Cystic Fibrosis in Intestinal Stem Cells; E.M. Slorach, J.R. Dorin. Section II: Growth and Development. 5. Gastrointestinal Development: An Overview; S.J. Henning. 6. Recent Insights into Roles for EGF Receptor Ligands in Epithelial Cell Systems; R.J. Coffey, et al. 7. Paba-Peptide Hydrolase: Just Another Digestive Enzyme? E.E. Sterchi. 9. Gastrointestinal Peptide Receptors and Neoplastic Growth Processes; J.C. Reubi. 10. Molecular Analysis of Novel Genes Differentially Expressed during Gut Development; G. Perozzi, et al. 11. Intestinal Proliferation and Infection in Childhood; T.C. Savidge, et al. 12. Perspectives on Stem Cells and Gut Growth: Tales of a Crypt - From the Walrus to Wittgenstein; I.M. Modlin, et al. Section III: Epithelial Mesenchymal Interactions. 13. Cellular and Molecular Mechanisms Regulating Intestinal Development; M. Kedinger, et al. 14. The Role of the Non-Integrin 67 kDa Laminin Receptor in Erythrocyte Proliferation, Adhesion and Motility; M.M. Weiser, et al. 15. Recent Work with Migration/Patterns of Expression: Cell-Matrix Interactions in Human Intestinal Cell Differentiation; J.-F. Beaulieu. 16. Recent Work with Hepatocyte Growth/Scatter Factor; A. Schmassmann, et al. 17. E-Cadherin/Catenin Complex in the Gastrointestinal Tract; M. Pignatelli, et al. 18. Molecular Aspects of Restitution; R. Poulsom. 19. Regulation of Epithelial Cell Proliferation and Differentiation in Small Bowel Adaptation after Resection and during Ontogeny; D.C. Rubin, M.S. Levin. 20. Protein Synthesis and Trafficking in Polarized Epithelia: The Parietal Cell Model; J.M. Crothers, Jr., et al. Section IV: Cell Differentiation. 21. Mechanisms of Sucrase-Isomaltase Gene Transcription: Implications for Intestinal Development; P.G. Traber. 22. Intestinal Mucin Gene Expression; J.R. Gum, Jr., et al. 23. Gastrointestinal Cell Lines as a Model for Differentiation; R.H. Whitehead, N.K. Watson. 24. Growth, Differentiation and Apoptosis: Mechanisms of Control and Deregulation during Colorectal Tumorigenesis; A. Hague, et al. 25. A Transgenic Model for Lactase Down-Regulation; J.T. Troelsen, et al. Index.