The Cytoskeleton in Health and Disease

ISBN-13: 9781493948802 / Angielski / Miękka / 2016 / 395 str.

Heide Schatten

Spis treści

Part 1. Overview of the Cytoskeleton.- Brief Overview of the Cytoskeleton.- Part 2. Focus on Cytoskeletal Interactions.- Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats.- Regulation of Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease.- The Role of the Cytoskeleton in Cell Migration, Its Influence on Stem Cells and the Special Role of GFAP in Glial Functions.- Centrosome-Microtubule Interactions in Health, Disease, and Disorders.- Cytoskeletal Elements and Reproductive Success in Animals.- Part 3. Focus on Microtubules.- Cytoskeleton and Regulation of Mitochondrial Translocation in Mammalian Eggs .- Tubulin Detyrosination in Epithelial Cells.- Mutations in Adenomatous Polyposis Coli, Their Role in Cytoskeletal Dynamics and Cancer Onset.- Small GTPases Act as Cellular Switches in the Context of Cilia.- Part 4. Focus on Intermediate Filaments.- Desmin Plays Dual Structural and Regulatory Functions Through Its Interaction with Partners in Muscle.- Desmin Filaments and Desmin-Related Myopathy.- Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes.- Part 5. Focus on Microfilaments.- Actin Organizing Proteins in Regulation of Osteoclast Function.- The Role of Drebrin-Binding Stable Actin Filaments in Dendritic Spine Morphogenesis.- The Role of the Actin Cytoskeleton in Cancer and Its Potential Use as a Therapeutic Target.

O autorze

Dr. Heide Schatten is Professor at the University of Missouri, Columbia, USA.  She is a cell biologist with research focused on cytoskeletal regulation in various cell systems and on cytoskeletal dysfunctions that play a role in disease such as cancer.

Her interest in cancer research was stimulated by father and sister physicians who as clinicians were faced with treating incurable diseases for which research on cell and molecular levels had not yet advanced to our current state of knowledge. She pursued her interest in research and received her M.S. and Ph.D. degrees from the Karl-Ruprecht University in Heidelberg, Germany, and performed her Ph.D. research studies at the German Cancer Research Center in Heidelberg to explore the mechanisms leading to abnormal cell divisions in cancer and to test drugs that prevent abnormal cell proliferation. She performed pre-and postdoctoral studies at the University of California, Berkeley, and entertained numerous collaborations with colleagues in the USA, Canada, Europe, China, and Latin America in the fields of reproduction and cancer using cell and molecular biology approaches. She has given numerous presentations in these and other countries. Her studies also included collaborations with NASA scientists and experiments aboard the Space Shuttle Endeavour to examine the effects of spaceflight on centrosome-cytoskeletal regulation during development. She also holds an M.S. degree in music from the School of Music in Heidelberg.

She is a member of the American Society for Cell Biology, American Association for the Advancement of Science, and Microscopy Society of America. She has received numerous awards including grant awards from NASA, NIH, and NSF.  She has published over 210 papers, 13 book chapters and edited several special topics journal issues and 9 books with several more in progress.

Blurb

This volume explores the cytoskeleton, examining its structural and functional roles and its dysfunctions which often lead to disease. Microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems are thoroughly discussed. The text is organized into four sections, each of which covers specific subtopics. These consist of an introductory chapter followed by topics of current interest and expert-provided contributions which include each topic's key cell and molecular details.

Comprehensive yet concise,  The Cytoskeleton in Health and Disease presents cutting- edge new knowledge balanced with background information, both of which are readily understandable for the newcomer and for the experienced researcher alike. The book highlights the new aspects of the research and its impact on  the design of new strategies or the identification of new targets for therapeutic intervention. This book will be essential reading for scientists, students, teachers who are interested in expanding their knowledge related to the cytoskeleton for diagnostic, therapeutic or research-based purposes.