The Biology of the Interferon System 1986: Proceedings of the 1986 Isir-Tno Meeting on the Interferon System, 7-12 September 1986, Dipoli Congress Cen

ISBN-13: 9789401080842 / Angielski / Miękka / 2011 / 579 str.

K. Cantell; H. Schellekens

Opis

Proceedings of the 1986 ISIR-TNO meeting held at the Dipoli Congress Center, Espoo, Finland, September 7-12, 1986

Spis treści

Genes and Proteins.- Amino acid residues affecting antiviral and antiproliferative activity in interferon-?’s.- Differential structures and activities of three IFN ?2 variants departing only at two amino acid positions.- Selective association of high density lipoprotein with interferon beta serine.- Structure, genetics and function of human ?2 interferon.- Tailoring of alpha interferons via in vivo recombination of the genes.- A new type of interferon-like protein produced by peripheral blood mononuclear cells treated with inhibitors of transcription.- Apparent auto-inhibition of murine interferon-? due to a serum component.- Modes of Action.- Nuclear localization of internalized interferons-? and -?: a role for nuclear receptors.- The 5? end of the human (2?-5?) oligo A synthetase gene contains sequences responsible for transcriptional activation by interferon.- Expression and preliminary deletion analysis of the 42 kDa 2-5A synthetase induced by human interferon.- The double-stranded RNA dependent protein kinase from human cells.- Homologs to mouse Mx protein induced by interferon in various species.- Comparative studies of the genomic structure of two human interferon induced genes.- Characterization of two new IFN-induced proteins.- Early events in the interaction of IFN-? with IFN-sensitive and IFN-resistant Daudi cells.- Receptors.- Some freshly EBV-transformed B-cell lines lack functional IFN-receptors.- Production of antibodies against the murine IFN-? receptor.- Purification and characterization of the receptor for human interferon-?.- Induction.- Interferon induction by transfection of Sendai virus C gene cDNA.- Studies on the expression of spontaneous interferon-like activity in mouse peritoneal cells.- Cellular factors mediate induction and superinduction of the human interferon-? gene.- Interferon beta-2 is constitutively expressed in human monocytes.- Regulation of human fibroblast growth by autocrine interferon-beta.- Biological activities of human interferon-?2 produced by cDNA expression in hamster cells and possible autocrine functions of this cytokine-induced IFN.- Cell Biology.- Overview of long-term IFN effects on the phenotype of transformed and tumor cells.- Mechanisms for anti-invasive effect of interferon.- Comparison of different modes of interferon delivery by tumor specific monoclonal antibodies.- Characterization of rat monoclonal antibodies to mouse interferon-? and -?.- Immunology and Interaction with other Lymphokines.- Molecular and cellular biology of tumor necrosis factor, interferon-?, and their synergism.- Induction of 26kDa protein mRNA in human cells treated with recombinant human tumour necrosis factor (rTNF).- Interactions of tumor necrosis factor, interferon and interleukin-1 in cell killing.- New relationships among IFN-gamma, TNF and IL-1: Cellular and biochemical effects.- Antagonistic effect of type I interferons on human macrophage activation by interferon-?.- Gamma-interferon regulates secretion of G-CSF in human monocytes on the transcriptional level.- Presence of tumor necrosis factor and lymphotoxin in clinical interferon preparations derived from leukocytes.- Phenotype of ?-interferon producing leukocytes.- Interferon regulates major histocompatibility class I gene expression through a 5? upstream regulatory region.- The antiviral effects of tumor necrosis factors.- Animal Models.- Interferon and tumor necrosis factor alter the phospholipid metabolism in Friend leukemia cell tumors in mice.- Antitumor effects of rat rec.IFN-? in rats bearing transplantable rat tumors.- Mechanisms of anticancer action of interferons on human tumour xenografts in nude mice.- IFN-gamma inhibits osteosarcoma xenografts in nude mice.- Transgenic mice carrying exogenous mouse interferon genes.- Studies on interferon in the bovine species: biological and biochemical effects.- Clinical Studies.- Antitumor effects.- Treatment of malignant endocrine pancreatic tumors with human leukocyte interferon.- Efficacy of alpha interferons in hairy cell leukemia (HCL) and status of the interferon system of patients in remission.- WellferonR efficacy in the treatment of hairy cell leukaemia (HCL).- Detection of urinary enzyme excretion as a parameter of the nephrotoxicity of human interferon alpha-2b in patients with hairy cell leukemia (HCL).- Interferon alfa-N1 WellferonR in Kaposi’s sarcoma: single agent or combination with vinblastine.- Combined interferon-polychemotherapy versus polychemotherapy in multiple myeloma: a phase-III study.- Recombinant interferon alpha (2A) combined with dacarbazine in treatment of metastatic melanoma.- Intralesional interferon-alpha-therapy in advanced malignant melanoma.- Comparison of clinical toxicity of natural alpha and recombinant gamma interferon. Results of phase II trials in lung cancer.- Antitumor activity of interferon-? against malignant glioma in combination with chemotherapeutic agent of nitrosourea (ACNU).- Interferon alpha in the treatment of malignant diseases: sources, doses, and regimens.- Treatment of various malignancies with recombinant IFN-?.- Interferons and interferon inactivators in AIDS, ARC and in cancer patients.- Overview: clinical trial with natural and recombinant interferons in China.- Interferon producing capacity in patients with liver disease, diabetes mellitus, chronic diseases and malignant diseases.- Antiviral effects.- Early treatment of the common cold with intranasal interferon alpha-2A (Ro 22-8181): a preliminary pilot study.- Long-term tolerance of intranasal recombinant interferon-?ser in man.- The role of alpha 2 interferon in combination with acyclovir in ophthalmic zoster (an open pilot study).- Production of a partially acid labile alpha interferon in cytomegalovirus pneumonitis.- Randomized controlled trial of a four month course of recombinant human alpha interferon in patients with chronic type B hepatitis.- Treatment of chronic hepatitis B infection with alpha (lymphoblastoid) interferon: responses in different social and ethnic groups in comparison to adenine arabinoside monophosphate.- Interferon alfa-n1 (Wellferon)R in severe recurrent genital warts: Report of a multi-study program.- Activity of intralesional interferon alfa-2B in viral and malignant skin diseases.- Effects on other diseases.- Idiopathic mixed cryoglobulinemia: a new therapeutic approach with alpha interferon.- Treatment of rheumatoid arthritis (RA) with interferon-gamma (IFN-gamma): Results of clinical trials in Germany.- Interferon in human breast cystic disease.- Efficacy of intratheçally administered natural human fibroblast interferon as treatment of multiple sclerosis.- A study on the efficacy of recombinant human ?D type interferon (rIFN-?D) in treatment of chronic cervicitis.- Presence and possible role of interferons in psoriasis.- The components of the interferon system in SLE and psoriasis.- Pharmacokinetics of (123I)-interferon (IFN) alpha-A.- Received after deadline.- 2?5? A synthetase activity is induced by a factor excreted in heat-shocked cells. Comparison of this factor with IFN.- Mapping the action of interferon on primate brain.- Chemical and biological characterization of natural human lymphoblastoid interferon alphas.- Author index.