The Amphipathic Helix

ISBN-13: 9780849349263 / Angielski / Twarda / 1993 / 416 str.

Epand M. Epand; Richard M. Epand

Opis

A comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, and mitochondrial targeting. It also includes general introductory material that defines amphipathic helices, and discusses methods to identify amphipathic helical segments.

Spis treści

Introduction and Overview (R.M. Epand). Design of Amphipathic Helices: Computational Techniques to Predict Amphipathic Helical Segments (I.E. Auger). Amphipathic Helices in Designed Peptide Structures (J.M. Stewart). The Role of Amphipathic Helices in Stabilizing Peptide and Protein Structure (C.T. Mant, N.E. Zhou, and R.S. Hodges). Experimental Methods for Studying Amphipathic Helices in Membranes: Polarized Attenuated Total Reflection Infrared Spectroscopy as a Tool to Investigate the Structure and Orientation of Amphipathic Peptides in a Lipid Bilayer (E. Goormaghtigh, V. Cabiaux, and J.-M. Ruysschaert). NMR Spectroscopy of Amphipathic Helical Peptides in Membrane Environments (S.J. Opella, J. Gesell, and B. Bechinger). Biological Roles for the Interactions of Amphipathic Helices with Lipids: An Atlas of the Amphipathic Helical Domains of the Human Exchangeable Plasma Apolipoproteins (G.M. Anantharamaiah, M.K. Jones, and J.P. Segrest). Amphipathic Helical Segments in Lung Surfactant Proteins (A.J. Waring, L.M. Gordon, H.W. Taeusch, and R. Bruni). The Amphipathic Helix in Cytotoxic Peptides (I. Cornut, E. Thiaudière, and J. Dufourcq). Amphipathic Helices and Ion Channels (J. Tomich). Other Biological Roles for Amphipathic Helices in Membrane-Related Phenomenon: The Amphipathic Helix in Mitochondrial Targeting Sequences (D. Roise). Amphiphilic Helices in Neuropeptides (J.W. Taylor). Activation of G Proteins by Membrane Receptors and Peptides. Putative Role for Amphipathic Helices (M. Mousli and Y. Landry). The Amphipathic Helix as a Structural Feature Involved in T-Cell Recognition (J.L. Cornette, H. Margalit, C. DeLisi, and J.A. Berzofsky). Other Biological Roles of Amphipathic Helices: Amphipathic Helices in Proteins that Bind to DNA: The bZIP and bHLH-Zip DNA Binding Motifs (C.R. Vinson). Protein-Ice Interactions: Antifreeze Proteins (D.S.C. Yang).

O autorze

Richard M. Epand