The Algebra of Organic Synthesis: Green Metrics, Design Strategy, Route Selection, and Optimization

ISBN-13: 9780367149642 / Angielski / Miękka / 2019 / 1124 str.

John Andraos

Opis

A how-to manual for quantitative analysis of material efficiency and synthesis strategy in chemistry, this book explains quantitative material efficiency and discusses the role of metrics analysis in actualizing the principles of green chemistry. It covers graph theory as it applies to organic synthesis, the simple mathematical analysis of organic synthesis, and how synthesis plans can be ranked in an unbiased way. The author illustrates the concepts with example target plans and classical targets considered milestones in synthetic chemistry from pharmaceuticals, dyestuffs, agrichemicals, insecticides, natural products, and molecules of theoretical interest.

Spis treści

Aims and Scope. General Comments on Organic Chemistry and Green Chemistry. Problems with Literature Reporting of Synthesis Plans. Problems and Challenges in Synthesis and Green Chemistry. Overview of Green Metrics. Optimization. Named Organic Reaction Database. Example Transformations Illustrating Sacrificial Reagents. Synthesis Strategies. Ring Construction Strategies. Example Highlights from Database. Summary of Overall Trends in Synthesis Database. Compounds with Multiple Plans. Appendix A. Appendix B. Index.

O autorze

John Andraos earned a Ph.D. in 1992 from the University of Toronto in physical organic chemistry. Since his appointment as Lecturer and Course Director at York University, he launched the first industrial and "green" chemistry course in the history of the Department of Chemistry. He has done consulting assignments with the pharmaceutical industry on various aspects of synthesis optimization and green chemistry education. His research spans several disciplines in organic chemistry which utilize mathematical analysis including reaction kinetics, retrosynthesis and synthesis planning, and the creation of reaction and ring construction databases. He is the author of 50 scientific papers in refereed journals and 6 book chapters on the subject of green chemistry metrics and education. In 2000 he launched the CareerChem website (http://www.careerchem.com/MainFrame.html) which is an in-depth resource for tracking and cataloguing all named things in chemistry and physics, chronicling the development of chemistry through scientific genealogies, and supplying career information to young researchers and students for placement in academic and industrial positions worldwide.