Testosterone and its dimers alter DNA and tRNA morphology

ISBN-13: 9783330866836 / Angielski / Miękka / 2017 / 72 str.

Heidar-Ali Tajmir-Riahi

Opis

The morphology of DNA and tRNA were altered by conjugation with testosterone and its aliphatic and aromatic dimers. Structural models showed that testosterone and its dimers bind DNA and tRNA via several nucleobases with DNA forming more stable conjugates than tRNA. The loading efficacies were 30-50% for these steroid-nucleic acid adducts. Transmission electron microscopy showed major changes in DNA and tRNA morphology upon testosterone conjugation with an increase in the diameter of DNA and tRNA aggregates, indicating encapsulation of testosterone by nucleic acids.

O autorze

Tajmir-Riahi H.A. Research Professor , Quebec University in Trois-Rivières (UQTR) Canada, Research interest: 1. Drug interactions with DNA, RNA and proteins. 2. Drug delivery by natural and synthetic nanoparticles, using microscopic and spectroscopic analysis. I have 300 publications in international journals and 10 book chapters