Telomeres in Health and Disease: Volume 125

ISBN-13: 9780123978981 / Angielski / Twarda / 2014 / 202 str.

Rodrigo Calado

Opis

This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field.

• Contributions from specialists in telomere diseases
• Informs and updates on how telomere dysfunction may cause disease in humans

Recenzje

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

Spis treści

1. Telomere and Telomerase Biology
   Miriam Aparecida Giardini, Marcela Segatto, Marcelo Santos da Silva, Vinícius Santana Nunes and Maria Isabel Nogueira Cano
2. Human Telomeres and Telomere Biology Disorders
   Sharon A. Savage
3. Telomere Biology in Stem Cells and Reprogramming
   Luis F. Z. Batista
4. Telomere Dynamics and Aging
   Geraldine Aubert
5. Telomeres in Molecular Epidemiology Studies
   Clara Bodelon, Sharon A. Savage and Shahinaz M. Gadalla
6. Telomere dysfunction and hematologic disorders
   Raquel M. A. Paiva and Rodrigo T. Calado
7. The Role of Telomeres in Liver Disease
   Yoshiaki Sunami, Guido von Figura, Alexander Kleger, Pavel Strnad, Norbert Hüser and Daniel Hartmann
8. Telomeres in lung diseases
   Rodrigo T. Calado
   

O autorze

Rodrigo Calado received his MD in 1997 and PhD in 2003 both from the University of São Paulo, Brazil. He was trained in hematology and did his postdoctoral fellowship at the U. S. National Institutes of Health in Bethesda, Maryland with Dr. Neal S. Young, where he also worked as a Staff Scientist between 2007 and 2011. He is currently Associate Professor of Medicine at the University of São Paulo in Ribeirão Preto, Brazil. Dr. Calado was the first to report on telomerase enzyme mutations in humans causing disease (aplastic anemia) and found that telomerase complex mutations also predisposed to leukemia and liver cirrhosis. He also demonstrated that short telomeres increase chromosome instability in humans and that sex hormones up-regulate telomerase function in hematopoietic cells.