Targeting of Drugs 5: Strategies for Oligonucleotide and Gene Delivery in Therapy

ISBN-13: 9780306455049 / Angielski / Twarda / 1996 / 206 str.

Gregory Gregoriadis; Brenda McCormack

Opis

The 19 papers explore a variety of systems in terms of their ability to transport nucleic acids to target areas in vitro and in vivo in ways that effectively modify, supplement, correct, or curtail the function of genes in therapy. Among the topics are cystic fibrosis, immune responses with direct g

Spis treści

Gene Therapy for Inherited Genetic Disease; Possibilities and Problems; C. Coutelle. Gene Delivery and Therapy: The Case for Cystic Fibrosis; E.W.F.W. Alton. Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy; H.L. Davis. Oligonucleotides: Molecular Versions for Optimal Use In Vivo; E. Saison-Behmoaras, et al. Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells; A.J. Kingsman, et al. Adenovirus as Vectors for Gene Therapy; M.G. Lee. Receptor-mediated Gene Delivery with Synthetic Virus-Like Particles; E. Wagner, et al. Controllable Gene Therapy-Recent Advances in Non-Viral Gene Delivery; A. Rolland. Genetic Chemistry: Towards Non-Enzymatic Ligation. Sequence-Selective Recognition of DNA and Self-Assembling Systems for Gene Delivery; J.-P. Behr. Integrin-Mediated Gene Delivery; S.L. Hart, et al. Design, Synthesis and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy; C.S.R. Gooden, A.A. Epenetos. 7 Additional Articles. Index.