Systems Biology in Drug Discovery and Development: Methods and Protocols

ISBN-13: 9781493957705 / Angielski / Miękka / 2016 / 337 str.

Qing Yan

Opis

Here is a practical, holistic view of the uses of systems biology to
achieve better drug discovery and personalized medicine. Leading experts describe cutting-edge technologies and show how they apply to understanding of disease and therapeutic discovery.

Recenzje

From the reviews:

"This book describes state-of-the-art technologies and methods in molecular biology and the necessary integration of data ... . The resultant book provides an effective resource for students, biologists, and physicians in multiple disciplines, as well as individuals involved in the drug development process. ... This is a very effective and comprehensive guide to the advances in molecular biology methods and computational tools that model complex biological systems as a means to better understand disease mechanisms and identify appropriate drug candidates for individualized therapies." (Rachel Renee Chennault, Doody's Review Service, February, 2011)

Spis treści

Part I: Methodologies of Systems Biology in Drug Discovery and Development 1. Proteomics and Systems Biology: Application in Drug Discovery and Development Bulbul Chakravarti, Buddhadeb Mallik, and Deb N. Chakravarti 2. Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-Target Drugs André Schrattenholz, Karlfried Groebe, and Vukic Soskic 3. Systems Biology “On-the-Fly”: SILAC-Based Quantitative Proteomics and RNAi Approach in D. Melanogaster Alessandro Cuomo and Tiziana Bonaldi 4. Systems Biology of Cell Behaviour Najl V. Valeyev, Declan G. Bates, Yoshinori Umezawa, Antonina N. Gizatullina, and Nikolay V. Kotov 5. Computational Modeling in Systems Biology Ravishankar R. Vallabhajosyula and Alpan Raval 6. An Introduction to Gaussian Bayesian Networks Marco Grzegorczyk 7. Derivation of Large-Scale Cellular Regulatory Networks from Biological Time Series Data Benjamin L. de Bivort 8. Translational Bioinformatics and Systems Biology Approaches for Personalized Medicine Qing Yan Part II: Systems Biology Methods for Disease Treatment and Translational Medicine 9. Systems Biology and Inflammation Yoram Vodovotz and Gary An 10. Immunoinformatics and Systems Biology Methods for Personalized Medicine Qing Yan 11. Systems Biology Approaches to the Study of Cardiovascular Drugs Yuri Nikolsky and Robert Kleemann 12. Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon, and David J. Harrison 13. Systemic Lupus Erythematosus: From Genes to Organ Damage Vasileios C. Kyttaris 14. Systems Biology of Influenza: Understanding Multi-Dimensional Interactions for Personalized Prevention and Treatment Qing Yan 15. Methods in Systems Biology of Experimental Methamphetamine Drug Abuse Firas H. Kobeissy, Shankar Sadasivan, Melinda Buchanan, Zhiqun Zhang, Mark S Gold, and Kevin K.W. Wang 16. Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic BrainInjury Zhiqun Zhang, Stephen F. Larner, Firas Kobeissy, Ronald L. Hayes, and Kevin K.W. Wang

Blurb

Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.