Synthesis and Characterization of Glycosides

ISBN-13: 9781441938770 / Angielski / Miękka / 2010 / 352 str.

Marco Brito-Arias

Opis

This book contains the best known approaches for preparing the main types of glycosides in a short and comprehensive study. It also includes synthetic pathways of challenging glycosides known as antiviral or antineoplasic drugs, or synthetic substrates used for enzymatic detection including those used as substrates for detection of gene markers in plant biotechnology. Special attention is made on the structural characterization, providing the basic tools for the structural assignment through NMR, X-Ray and mass spectra techniques. Some of the chapters cover strategies for preparation of antiviral and antineoplasic drugs included in a drug design course.

Recenzje

From the reviews:

"Brito-Arias ... provides an overview of the structures and synthetic preparations of O-, N-, and C-glycosides, as well as discussion of the conformational features and biological function of selected examples. ... The organization of the book provides a ready resource for researchers seeking information. Indeed, the references to published synthetic methodology or analytical data included at the end of each chapter will be useful for researchers seeking additional information or details on a specific topic. ... Summing Up: Recommended. Graduate students through professionals." (P. W. Baures, CHOICE, Vol. 44 (11), July, 2007)

Spis treści

Glycosides, Synthesis, and Characterization.- O-Glycoside Formation.- N-Glycosides.- Nucleoside Mimetics.- C-Glycosides.- Glycoconjugates.- Hydrolysis of Glycosides.- Nuclear Magnetic Resonance of Glycosides.- X-Ray Diffraction of Glycosides.- Mass Spectrometry of Glycosides.