Synthesis and Biological Screening of Some Sulfonamides & Oxadiazoles

ISBN-13: 9783659285721 / Angielski / Miękka / 2014 / 64 str.

Rehman Aziz-Ur-

Opis

In the present study, various N-alkyl substituted derivatives of benzene-sulfonamide were synthesized. In the first step, benzene sulfonyl chloride was treated with 2-amino-2-methyl-1-propanol afforded N-(2-hydroxy-1,1-dimethylethyl)-benzenesulfonamide and in next step this parent compound was reacted with alphatic halides to produced different N-alkylation substituted derivatives. Oxadiazole are very important compounds that are strongly biologically active. In this study the parent compound 5-benzyl-1,3,4 oxadiazole-2-thiole was synthesized by hydrazinolysis of ethyl phenylacetate followed by reaction with carbon disulfide. Further the parent compound oxadiazole was treated with different aliphatic alkyl groups to produce eight different S-substituted derivatives of oxadiazole. All these synthesized derivatives of sulfonamides and oxadiazoles were characterized by melting point, IR, EI-MS, 1H-NMR and X-ray crystallographic techniques. These compounds were screened.to evaluate their biological activity and only sulfonamides showed inhibition potentials against butyrylcholinesterase.

O autorze

He is currently working as an Associate Professor in the Department of Chemistry GC University, Lahore, Pakistan. He has more than 115 scientific research articles in the field of organic chemistry. He is HEC approved PhD supervisor and awarded Research Productivity Award-2011-12 by PCST. He is also a Managing Editor of the scientific Ravi.