1. General Introduction 2. Recent advances in tritium chemistry 3. Recent advances in carbon-14 chemistry 4. Recent advances in the chemistry of PET and SPECT isotopes 5. Recent advances in the chemistry of stable isotopes 6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds 7. Non pharmaceutical applications of labelled compounds 8. Emerging new fields in the chemistry of isotopes and their application 9. Deuterated APIs 10. Recent advances in the analysis of isotopically labelled compounds 11. Radiolabeling of large molecules 12. Summary and outlook