Synthesis, Characterization, Antimicrobial, Cns and Analgesic Studies : of 2-[N-(4-chloro-2-{[1-(2hydroxyphenyl) ethylidene]amino} phenyl) ethanimidoyl] phenol AND ITS COMPLEXES

ISBN-13: 9786200550224 / Angielski

Deivanayagam P.

Opis

4-Chloro-O-Phenylene diamineand itsCopper (II) complexhave been prepared by theSchiff base formation.The synthesizedcompound was confirmed from UV, IR & NMR spectrum. The O-Phenylene diamine and its Copper (II) complex found to have remarkable antimicrobial activity due to the presence of nitrogengroup.The antimicrobial activities ofthree bactericidalorganisms Bacillus subtilis, StreptococcusviridiansandStaphylococcus epidermidison the test compounds 4-Chloro-O-Phenylene diamine and its Copper (II) complex were screened by employing the Disc Diffusion method. A concentration gradient (500, 1000, 2000and 3000 g) of each compound was put into study. From the study, it is observed thatits shows a maximum zone of inbition. 2-hyroxy acetophenone and 4 -chloro -o-phenylene diamine were refluxed in ethanol and the product is 2-[N-(4-chloro-2-{[1-(2-hydroxyphenyl)ethylidene]amino}phenyl)ethanimidoyl]phenolandits complexes were prepared. The product was confirmed byTLC, IR, 1H NMR and UVStudies. The product was subjected to antibacterial activity and it shows a goodantibacterial activity.

O autorze

P., Deivanayagam
P. Deivanayagam - B. Sc chemistry in Sri paramakalyani college, Alwarkurichi, M. Sc pharmaceutical chemistry in Sri kaliswari college, Sivakasi, M.phil chemistry in muthayammal college of arts and science and Ph.D in chemistry in Sri paramakalyani college Alwarkurichi.