Studies on Cardiovascular Disorders

ISBN-13: 9781617797071 / Angielski / Miękka / 2012 / 590 str.

Heinrich Sauer; Ajay M. Shah; Francisco R. M. Laurindo

Opis

The role of reactive oxygen species (ROS) in the cardiovascular system is Jan- faced. Whereas low concentrations of ROS are involved in variety of physiological signalling events, oxidative stress resulting from deregulated overproduction of ROS and/or impaired antioxidant defences contributes to cardiovascular disease. The actions of ROS in the cardiovascular system are a fascinating topic, not only for the basic science researcher but also for the clinician who is interested in seeking new therapies for his patients suffering from cardiovascular disease. The current book provides a comprehensive overview of the molecular mechanisms and pathoph- iological settings in which chronic and detrimental oxidative stress arises within the heart and vasculature. The book also considers currently discussed strategies in avoiding chronic redox stress resulting from exposure to risk factors or various cardiovascular interventions. The series starts with an overview by Denise de Castro Fernandes, Diego Bonatto and Francisco Laurindo of redox signaling models that could underlie the dev- opment of redox-associated cardiovascular disorders. The interactions of proteins within signalling cascades with ROS and the regulation of such interactions by the anti-oxidative capacity of the cell are discussed. Rebecca Charles, Joseph Burgoyne and Philip Eaton report on redox-mediated modi cations of proteins under ph- iological and pathophysiological conditions and the variety of post-translational oxidative modi cations that explain redox sensing and signal transduction by proteins at the molecular level. ROS are generated during embryogenesis and may be involved in the proper development of the cardiovascular system.

Recenzje

From the reviews:

"This is a collection of articles that provides insight into the evolving field of oxidative stress. ... It is intended for students, physicians in training, clinicians, and cardiovascular researchers interested in oxidative stress. ... This collection of articles with color diagrams provides a unique, well-organized, and clinically relevant resource on a vast range of topics relating to oxidative stress. This book will be a solid resource in this rapidly changing field." (Paul Michael, Doody's Review Service, February, 2011)

Spis treści

Preface Contributor’s List Chapters: 1) The evolving concept of oxidative stress Denise de Castro Fernandes, Diego Bonatto, Francisco R. M. Laurindo 2) Mechanisms of redox signaling in cardiovascular disease Rebecca L. Charles, Joseph R. Burgoyne and Philip Eaton 3) Reactive oxygen and nitrogen species in cardiovascular differentiation of stem cells Heinrich Sauer and Maria Wartenberg§ 4) Reactive Oxygen Species (ROS) and the sensory neurovascular component Rabea Graepel BSc, Jennifer Victoria Bodkin BSc, MRes, & Susan Diana Brain BSc, PhD 5) Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Post-Conditioning Ariel R. Cardoso, Bruno B. Queliconi* and Alicia J. Kowaltowski 6) Coenzyme Q9/Q10 and Healthy Heart Samarjit Das, Somak Das and Dipak K. Das 7) Oxidative and proteolytic stress in homocysteine associated cardiovascular diseases Karni S. Moshal, Munish Kumar, Neetu Tyagi, Paras Kumar Mishra, Saumi Kundu, Suresh C. Tyagi 8) Functional studies of NADPH oxidases in human vasculature Tomasz J Guzik 9) Relationship of the CYBA gene polymorphisms with oxidative stress and cardiovascular risk Guillermo Zalba, PhD and Javier Díez, MD, PhD 10) Redox-related genetic markers of cardiovascular diseases Christian Delles, MD, and Anna F. Dominiczak, MD 11) NADPH oxidases and blood-brain barrier dysfunction in stroke Timo Kahles, MD, Sabine Heumüller and Ralf P. Brandes, MD 12) Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular Diseases David Bernhard PhD 13) Oxidative Stress in Vascular Aging Anna Csiszar, MD, PhD and Zoltan Ungvari, MD, PhD 14) Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus Divya Gupta, Kathy K. Griendling and W. Robert Taylor 15) Reactive Oxygen Species, Oxidative Stress and Hypertension Rhian M Touyz MD, PhD, Andreia Chignalia, MSc, Mona Sedeek PhD 16) Peripartum cardiomyopathy: Role of STAT-3 and reactive oxygen species Denise Hilfiker-Kleiner, PhD, Arash Haghikia, MD, andAndres Hilfiker, PhD 17) Oxidative stress and inflammation after coronary angiography Raymond Farah MD 18) Oxidative Stress in Cardiac Transplantation Galen M. Pieper, Ph.D. and Ashwani K. Khanna, Ph.D 19) Oxidative Stress and Atrial Fibrillation Ali A. Sovari and Samuel C. Dudley, Jr. 20) Oxidative stress and the anti-oxidative capacity in myocardial infarction Yao Sun, MD, Ph.D. 21) Oxidative Stress and Redox Signalling in Cardiac Remodelling Min Zhang MD, PhD, Alex Sirker MRCP and Ajay M Shah MD, FmedSci 22) Oxidative Stress and Cardiovascular Fibrosis Subramanian Pennathur, Louise Hecker, and Victor J. Thannickal 23) Oxidative Risk Factors for Cardiovascular Disease in Women M. Gago-Dominguez, Xuejuan Jiang, J. Esteban Castelao 24) Protective effects of food on cardiovascular diseases Alfonso Giovane, Biol.D., Ph.D., and Claudio Napoli, M.D., Ph.D., MBEth. 25) Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications Gloria V. López , PhD and Homero Rubbo, PhD 26) Thioredoxin in the cardiovascular system – towards a thioredoxin-based anti-oxidative therapy Bradford C. Berk 27) The protective effect of melatonin on the heart Amanda Lochner 28) Exercise Induced cardioprotection: Overview with an emphasis on the role of anti-oxidants Karyn L. Hamilton and John C. Quindry 29) Antioxidative properties of statins in the heart Oliver Adam MD, Ulrich Laufs MD

Blurb

This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.