Structural and Catalytic Roles of Metal Ions in RNA

ISBN-13: 9783110442823 / Angielski / Twarda / 2015 / 423 str.

Astrid Sigel;Helmut Sigel;Roland K.O. Sigel

Opis

This book describes structural and catalytic roles of metal ions in RNA in an authoritative and timely manner. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The spliceosome, the ribosome, ribozymes involving redox cofactors as well as the binding of kinetically inert metal ions to RNA are also covered.

Spis treści

From the Content:

• Metal Ion Binding to RNA
• Methods to Detect and Characterize Metal Ion Binding Sites in RNA
• Importance of Diffuse Metal Ion Binding to RNA
• RNA Quadruplexs
• The Roles of Metal Ions in Regulation by Riboswitches
• Metal Ions: Supporting Actors in the Playbook of Small Ribozymes
• Multiple Roles of Metal Ions in Large Ribozymes
• The Spliceosome and Its Metal Ions
• The Ribosome: A Molecular Machine Powered by RNA
• Metal Ion Requirements in Artificial Ribozymes that Catalyze Aminoacylation and Redox Reactions
• Metal Ion Binding and Function in Natural and Artificial Small Ribozymes from a Structural Perspective
• Binding of Kinetically Inert Metal Ions to RNA: The Case of Platinum(II)

O autorze

Helmut und Astrid Sigel, University of Basel, Switzerland. Roland K. O. Sigel, University of Zürich, Switzerland.