Structural Genomics and High Throughput Structural Biology

ISBN-13: 9780367392239 / Angielski / Miękka / 2019 / 304 str.

Michael Sundstrom; Martin Norin; Aled Edwards

Opis

Assembled by leaders from the Structural Genomics Consortium at Oxford and Toronto Universities, one of the largest research efforts in the world, this book details state-of-the-art analytical and computational methods used to reveal the three-dimensional structure of proteins and explains how to interpret the information to elucidate protein function. From basic discovery through practical applications of therapeutically driven structural genomics, this book presents a comprehensive overview of the field. It features the works and experience of leading international experts and editors who convey extensive practical insight and suggest future directions in the field.

Spis treści

Overview of Structural Genomics: Landscape, Premises, and Current Direction. Purifying Protein for Structural Biology. Protein Crystallization: Automation, Robotization and Miniaturization. NMR Spectroscopy in Structural Genomics. High Throughput Protein Crystallography. From Sequence to Function. Comparative Modeling and Structural Proteomics. Ab Initio Modeling. Determining Function from Structure. Retrieval and Validation of Structural Information. Problems in Computational Structural Proteomics. Therapeutically-Driven Structural Genomics.

O autorze

Michael Sundström, Martin Norin, Aled Edwards