Stimulus-Secretion Coupling in Neuroendocrine Systems

ISBN-13: 9783642734977 / Angielski / Miękka / 2011 / 256 str.

Detlev Ganten; Donald Pfaff

Opis

The role of electrical signalling in the control of endocrine secretions by the brain has been clear for many years. Recently, the influences of hormones on synthetic events in neuroendocrine cells have raised new questions concerning the peptides released from such neurons. This volume concentrates on the relation between these two fields and asks how electrical action potentials facilitate secretion of substances from nerve cells which control endocrine events. While stimulus-secretion coupling has been studied extensively in other physiological contexts, this is the first treatment of the phenomenon in an exclusively neuroendocrine setting.

Spis treści

Cellular Reorganization in Neuroendocrine Secretion.- Stimulus-Secretion Coupling in the Oxytocin System.- Coupling of Electrical Activity and Hormone Release in Mammalian Neurosecretory Neurons.- The Bag Cell Neuroendocrine System of Aplysia.- Electrophysiological Characteristics of Peptidergic Nerve Terminals Correlated with Secretion.- Changes in Information Content with Physiological History in Peptidergic Secretory Systems.- Insect Neuropeptides.- Stimulus-Secretion Coupling in the Pancreatic B Cell.

O autorze

Detlev Ganten, geb. 1941, zählt zu den herausragenden Persönlichkeiten in der europäischen Forschungslandschaft. Er ist u.a. Gründungsdirektor des Max-Delbrück-Centrums für molekulare Medizin, Professor für Klinische Pharmakologie an der FU Berlin, Mitglied im Nationalen Ethikrat und Vizepräsident der Berlin-Brandenburgischen Akademie der Wissenschaften.