Steric and Stereoelectronic Effects in Organic Chemistry

ISBN-13: 9789811093395 / Angielski / Miękka / 2018 / 211 str.

Veejendra K. Yadav

Spis treści

Steric and Stereoelectronic Control of Organic Molecular Structures and Organic Reactions.- Reactions at Saturated and Unsaturated Carbons.- Diastereoselectivity in Organic Reactions.- A(1,2) and A(1,3) Strains.- The Conservation of Orbital Symmetry (Woodward-Hoffmann Rules).- The Overlap Component of the Stereoelectronic Factor vis-à-vis the Conservation of Orbital Symmetry Rules.- Miscellaneous.

O autorze

Veejendra K. Yadav earned his PhD under the mentorship of Dr. Sukh Dev in 1982. He has carried out his postdoctoral research at University of Calgary, Memorial University of Newfoundland, University of Ottawa, and University of Southern California over the years 1983–1990 before joining Indian Institute of Technology Kanpur (IITK) as Assistant Professor in late 1990. Over the years, he rose through ranks and became full Professor in 2001. He has taught both undergraduate and postgraduate students at IITK over the past twenty five years, and has remained a popular teacher among the students throughout. His research focuses on development of new reactions with emphasis on the construction of pharmacophores, synthesis of biologically active molecules, and computational-cum-experimental investigation of facial selectivity. He has two international patents and 80 research papers in peer reviewed journals to his credit. 

 

Blurb

The steric and stereoelectronic effects control the rate and stereochemical outcome of reactions. Hence, a decent understanding of the related concepts is essential for successful synthetic planning. The book attempts to address several important issues related to these concepts in a simplified manner, and is intended for graduate students. It lays stress on the important aspects of steric and stereoelectronic effects and their control on the conformational profile and reactivity features. The book covers the geometrical requirements for reactions at saturated and unsaturated carbons in both cyclic and acyclic systems, and the resultant stereochemical features. The aspect of geometrical flexibility is also covered with a few examples involving intramolecular reactions. It deals with the facial selectivity of nucleophilic additions to acyclic and cyclic carbonyl compounds, and explains how the steric and stereoelectronic effects control the same. The work comments on allylic strains and their stereochemical control on different reactions with the related conformational control. It is a must read to understand the control elements, the prominent among these elements are spiro-conjugation, periselectivity, torquoselectivity, a-effect, Hammett’s substituent constants, Hammond postulate, and Curtin-Hammett principle.