Somatostatin

ISBN-13: 9781402077999 / Angielski / Twarda / 2004 / 311 str.

Coimbatore B. Srikant; Coimbatore B. Srikant

Opis

- Each chapter is written by expert(s) active in somatostatin research (experimental and/or clinical) - It will serve as the only single one-stop source of the most up to date information on the basic and clinical aspects of the biology of somatostatin

Recenzje

"Since the discovery of somatostatin barely 30 years ago, the mechanism of action of this ubiquitous peptide has been rigorously investigated. This volume contains a comprehensive tour de force of advances in molecular, cellular, and physiologic aspects of somatostatin function and action, will be a useful resource for understanding current concepts of this hormone action, and also illuminates future directions for further investigation in this important area of peptide biology."
(Shlomo Melmed, M.D., Series Editor, Endocrine Updates)

Spis treści

Preface; C.B. Srikant. Note on Nomenclature; C.B. Srikant. Contributors. Somatostatin - General Biology. 1. Somatostatin Gene Structure and Regulation; M. Vallejo. 2. Processing and Intracellular Targeting of Somatostatin; R. Mouchantaf, Y.C. Patel, U. Kumar. 3. Cortistatin - A Novel Member of the Somatostatin Gene Family; V. Fabre, A.D. Spier, R. Winsky-Sommerer, J.R. Criado, L. de Lecea. 4. Molecular Evolution of Somatostatin Genes; H. Tostivint, M. Trabucchi, M. Vallarino, J.M. Conlon, I. Lihrmann, H. Vaudry. 5. Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice; M.J. Low, M. Rubinstein, V. Otero-Corchon. Expression and Function of Somatostatin Receptors. 6. Somatostatin Receptor Gene Family - Subtype Selectivity for Ligand Binding; J.P. Hannon, C. Bruns, G. Weckbecker, D. Hoyer. 7. Expression of Somatostatin Receptors in Human Tissues in Health and Disease; J.C. Reubi, B. Waser, J.-C. Schaer. 8. Coexpression of Multiple Somatostatin Receptors in Individual Cells; R. Gardette, F. Petit, S. Peineau, C. Lanneau, J. Epelbaum. 9. Somatostatin Receptor Subtype Selectivity for Cytotoxic and Cytostatic Signaling; C.B. Srikant. 10. Somatostatin Receptor Signaling via Protein Tyrosine Phosphatases; H. Lahlou, J. Guillermet, F. Vernejoul, S. Pyronnet, C. Bousquet, L. Buscail, C. Susini. 11. Expression and Function of Somatostatin and Its Receptors in Immune Cells; D.E. Elliott. 12. Physiology of Somatostatin Receptors: From Genetics to Molecular Analysis; H.-J. Kreinkamp, Chong Wee Liew, D. Bächner, M.-G. Mameza,M. Soltau, A. Quitsch, M. Christenn, W. Wente, D. Richter. Applications in Disease. 13. Somatostatin Receptor Imaging; D.J. Kwekkeboom, M. de Jong, E.P. Krenning. 14. Somatostatin Analogs in the Treatment of Pituitary Tumors; A. Colao. 15. Somatostatin Receptor Targeted-Radio-Ablation of Tumors; M. de Jong, R. Valkema, D.J. Kwekkeboom, E.P. Krenning. 16. Somatostatin Analogue Therapy of Neuro-Endocrine Gastro-Entero Pancreatic Tumors; K. Öberg. 17. Vascular Effects of Somatostatin; P. Häyry, E. Aavik. 18. The Use of Somatostatin Analogues in Diabetic Retinopathy; L.E.H. Smith, M.B. Grant. The Future. 19. Somatostatin and Its Receptors: Past, Present and the Future; C.B. Srikant. Index.