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This volume presents the most recent results of research in the study of sepsis and the new treatments that have become available, mortality rate however still being high.
Introductory Remarks.- Sepsis and Organ Dysfunction — Basics, Controversies, Rationale.- Sepsis and Organ Dysfunction: From Chaos to Rationale.- Alveolar Epithelium in Host Defence: Cytokine Production.- Phagocytosis and Lung Injury.- Dual Role of Neutrophil ?-Defensins in Lung Inflammation.- Epithelial Injury in Sepsis and ARDS: Role of Leukocyte-Derived Proteases.- Pro-and Anti-Inflammatory Cytokines and Apoptosis in Acute Lung Injury.- The Role of Interleukin-10 During Systemic Inflammation and Bacterial Infection.- Cardiovascular Surgery: Modulation of the Inflammatory Reaction.- Microcirculation in Critical Illness.- Microbial Translocation: From Myth to Mechanism.- Empirical Antibiotic Treatment in ICU Patients.- Rotation of Antibiotics — A New Strategy for Prescription in the Intensive Care Unit.- Diagnostic Approach to Sepsis — State of the Art.- Septic Shock Therapy.- Sepsis Trials in Children.- Sepsis and Clinical Trials: A New Era in Anti-Sepsis Therapies.- Evolving Concept and Challenges in Sepsis and MODS.