Sepsis: An Interdisciplinary Challenge

ISBN-13: 9783642830853 / Angielski / Miękka / 2011 / 391 str.

K. Reinhart; K. Eyrich

Opis

Despite the progress that has been made in intensive care medicine, sepsis and septic shock are still accompanied by a high mortality rate. In recent years, new therapeutic approaches have been developed on the basis of a better understanding of this complex condition. This monograph contains contributions by well-known scientists and clinicians in the fields of hygienics, microbiology, infectious diseases, physiology, surgery and intensive care medicine. It provides an up-to-date overview of the etiology, pathophysiology, prevention, and therapy of sepsis and its complications.

Spis treści

Sepsis: Clinical Definition and Incidence.- Epidemiology, Clinical Course, and Prognosis of Sepsis in 691 Patients.- Predisposing Factors and Host Defense Response to Sepsis and Septic Shock.- Pathophysiology of Sepsis and Septic Shock.- New Methods in the Microbiological Diagnosis of Septicemia.- Early Clinical, Laboratory and Hemodynamic Indicators of Sepsis and Septic Shock.- Useful and Useless Measures for Prevention of Infections and Sepsis in Intensive Care Patients.- Pattern of Endocrine Secretions in Sepsis.- Therapeutic Possibilities in the Adult Respiratory Distress Syndrome Associated with Sepsis.- Corticosteroids and Nonsteroidal Anti-inflammatory Agents in the Sepsis Syndrome.- Circulatory Abnormalities in the Sepsis Syndrome.- Sepsis and Myocardial Function.- Oxygen Transport and Tissue Oxygenation in Sepsis and Septic Shock.- Mechanisms of Limited Oxygen Delivery in Sepsis and Adult Respiratory Distress Syndrome.- Changes in the Microcirculation in Sepsis and Septic Shock.- Cellular and Subcellular Functions of Vital Organs in Sepsis — Multiorgan Failure.- Sepsis and Leukocyte Function: Harm and Benefit.- Mediators in the Pathogenesis of Septic Shock — State of the Art.- Problems of Sepsis in Newborns.- Crystalloids versus Colloids in Septic Shock.- Metabolic Support in Sepsis: Current Concepts and Future Perspectives.- Prevention and Therapy of Sepsis in the High-Risk Surgical Patient.- Indication for Relaparotomy in Postoperative Sepsis.- Clinical Relevance of Endotoxin and Eicosanoids in Severe Sepsis.- Role of Antibodies in Bacterial Sepsis.- Immunotherapy and Immunoprophylaxis of Sepsis.- The Effect of Antibiotics on the Biosynthesis of Proteins.- Antimicrobial Therapy of Septicemia.- Metabolic Changes in Sepsis and Septic Shock.- Role of Opioid Antagonists in the Therapy of Septic Shock.- New Concepts in the Pharmacological Treatment of Cardiocirculatory Failure in Septic Shock.