SYNTHESIS OF SOME NEW IMIDAZOLE DERIVATIVES VIA SCHIFF BASES

ISBN-13: 9786204201443 / Angielski / Miękka / 72 str.

Husam Khalaf; Dheefaf Hassan; Zainab Hassan

Opis

This book involves synthesis of a number of imidazole derivatives starting with Schiff bases. N-benzylidineareneamines (I) synthesized by condensation of primary aromatic amines with aromatic aldehydes in boiling ethanol. Benzene sulfonyl chloride reacts with these Schiff bases in dry benzene to give N-( -chloridbenzyl) benzene sulfonanilides (II). The later undergo a nucleophilic substitution reaction with thiourea in basic medium to give the corresponding iso-thiourea derivatives: -[N-aryl-N-benzenesulfonyl] aminobenzyl-iso-thiourease(III). These iso-thioureas(III) are condensed with bezoin in DMF to offer imidazole derivatives: -[N-aryl-N-benzenesulfonyl] aminobenzyl-2-thio-4,5diphenyl imidazole (IV).Some imidazole derivatives have anti-inflammatory, anti-arthritic, anti-allergic and immune stimulating activity; therefore, we hope that our prepared compounds may have biological activity.

O autorze

Khalaf, HusamHusam S. Khalaf, Ph.D. , M.Sc. and B.Sc. of Chemistry from University of Baghdad, Iraq. He is Currently Asst. Prof. Dr. of Analytical Chemistry at University of Baghdad, Baghdad, Iraq.