Rnai Technology

ISBN-13: 9781138114340 / Angielski / Miękka / 2017 / 392 str.

R. K. Gaur (Mody Institute of Technology; Bet Dagan Yedidya Gafni (Volcani Center; Directorate P. Sharma (Senior Scientist

Opis

RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA interference in microorganisms, plants, and animals, this book reviews the selective and robust effect of RNAi on gene expression. This process is essential both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest.

Spis treści

Foreword, Preface, List of Contributors, 1. Acute RNA Interference for Basic Research and Therapy, 2. Deciphering post-transcriptional Gene Silencing Pathways Through Genetic Screens, 3. Implications of miRNA-directed Gene Silencing in Cancer, 4. MicroRNA Interference: Concept and Technologies, 5. Silencing the Disease Messengers: Progress and Prospects in Developing Nucleic Acid based Therapeutics, 6. Artifi cial MicroRNA: A Third Generation RNAi Technology, 7. Pectin Methylesterase Enhances Tomato Bushy Stunt Virus P19 RNA Silencing Suppressor Effects, 8. MicroRNAs: A New Paradigm For Gene Regulation, 9. A RNAi-based Genome-wide Screen to Discover Genes Involved in Resistance to Tomato Yellow Leaf Curl Virus (TYLCV) in Tomato, 10. RNAi for Crop Improvement, 11. RNA Silencing and Viral Encoded Silencing Suppressors, 12. Gene Silencing and its Applications in Plants, 13. Use of RNAi Technology for Control of Rice Viruses, 14. Use of RNAi Technology in Medicinal Plants, 15. RNA Interference and Wheat Functional Genomics, 16. Biogenesis, Processing and Function of miRNA in Plants and Animals, 17. RNA Interference in Fungi, 18. Virulence of Fusarium spp. Causing Wilt Disease of Guava with Special Reference to RNAi, 19. RNA Interference—Interactomics and Therapeutics, Index, Color Plate Section

O autorze

R. K. Gaur, Yedidya Gafni, P. Sharma, V. K. Gupta