Reproductive Toxicology

ISBN-13: 9781420073430 / Angielski / Twarda / 2009 / 420 str.

Robert W. Kapp; Rochelle W. Tyl

Opis

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research. This ground-breaking resource includes:

• New and important critical mechanistic topics such as epigenetics and omics
• The first significant compilation of epigenetic mechanisms
• An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction
• New guidelines with respect to the latest research applications in the field

Spis treści

Section I: Normal Reproduction and Development. 1. Biology and Physiology of Fertilization. 2. Normal Development of the Male Reproduction System. 3. Normal Development of the Female Reproduction System. 4. Development of the Mammalian Nervous System. Section II: Regulatory Evaluation of Reproduction. 5. EPA and OECD Perspectives on Reproductive and Developmental Toxicity Testing. 6. FDA and ICH Perspectives on Reproductive and Developmental Toxicity Testing. 7. Reproductive Study Evolution and IND Submissions. Section III: Developmental Toxicity of Systemic Organ Systems. 8. Developmental Immunotoxicity. 9. Developmental Neurotoxicity. 10. Developmental Toxicology of the Respiratory System. 11. Developmental Toxicology of the Renal System. 12. Developmental Toxicology of the Liver. 13. Cardiovascular Development and Malformation. Section IV: Toxicity of the Reproductive Process. 14. Male Reproductive Toxicity. 15. Female Reproductive Toxicity. 16. Toxicity of Pregnant Female Reproductive System. 17. Epigenetic Reproductive Toxicants. 18. Endocrine Disruption Effects on Reproductive Development and Adult Reproduction. 19. Metals and Metal Compounds in Reproductive and Developmental Toxicology. 20. -omics in Reproductive and Developmental Toxicology.

O autorze

Robert W. Kapp, Rochelle W. Tyl