Regulatory T Cells in Health and Disease: Volume 136

ISBN-13: 9780128034156 / Angielski / Twarda / 2015 / 300 str.

Liston, Adrian

Opis

Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

• Contains contributions from leading authorities in the field of regulatory T cell biology
• Informs and updates on all the latest developments in the field
• Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer

Spis treści

1. Transcriptional and Epigenetic Regulation of Regulatory T Cell Development
   Yohko Kitagawa, James Badger Wing and Shimon Sakaguchi
2. Microenvironment Matters: Unique Conditions within Gut Draining Lymph Nodes Favor Efficient de Novo Induction of Regulatory T Cells
   Maria Pasztoi, Joern Pezoldt and Jochen Huehn
3. The Roles of the Nf-?b Pathway in Regulatory T Cell Development and Function
   Thomas S. Fulford, Darcy Ellis and Steve Gerondakis
4. The Molecular Control of Regulatory T Cell Induction
   Annemarie van Nieuwenhuijze and Adrian Liston
5. The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells
   Matthias Lochner, Zuobai Wang and Tim Sparwasser
6. Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes
   Maxime Dhainaut and Muriel Moser
7. Development and Function of Effector Regulatory T cells
   Peggy P. Teh, Ajithkumar Vasanthakumar and Axel Kallies
8. Treg Cell Differentiation: from Thymus to Peripheral Tissue
   David M. Richards, Michael Delacher, Yael Goldfarb, Danny Kägebein,  Ann-Cathrin Hofer, Jakub Abramson  and Markus Feuerer
9. Regulatory T Cells in Arthritis
   Noriko Komatsu and Hiroshi Takayanagi
10. The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and  Anti-Inflammatory Outcomes Upon Infection
    Laura E. Richert-Spuhler and Jennifer M. Lund
11. Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential
    Vitalijs Ovcinnikovs and Lucy S.K. Walker
    

O autorze

Adrian Liston is Professor in Autoimmune Genetics at the University of Leuven and the VIB, Belgium. His PhD research was on T cell tolerance and diabetes with Professor Chris Goodnow at the Australian National University, followed by post-doctoral research on regulatory T cell biology with Professor Sasha Rudensky at the University of Washington. The Liston laboratory is supported by an ERC Start Grant, a JDRF Career Development Award, a VIB Investigators Award and grants from the FWO and KUL. Adrian Liston has published more than 70 papers, with over 3000 citations, including key publications on the function of Aire in thymic tolerance, defective tolerance in the NOD mouse, the contribution of immunodeficiency to autoimmunity, microRNA function in regulatory T cells, the discovery of the follicular regulatory T cell, the role of microRNA in the thymic epithelium and the homeostatic control over regulatory T cells.