Regulation of Gene Expression by Small RNAs

ISBN-13: 9780849391699 / Angielski / Twarda / 2009 / 450 str.

Gaur (Rajesh) K.

Opis

Recent research demonstrates that defects in the processing mechanisms of small non-coding RNAs are linked to various human diseases. This text explores the latest research on microRNAs and their functional roles in cells and organisms. Written by international experts, discussion will include the identification, characterization, and structure-function analysis of microRNAs; the study of microRNAs in development, cancer, and viruses; and the applications of microRNAs with respect to gene regulation, functional genomics and therapeutics. This book is a valuable reference for established researchers and is also suitable for postdoctoral and clinical fellows, and graduate students.

Spis treści

IDENTIFICATION AND CHARACTERIZATION OF MICRORNAs. Experimental Approaches. Computational Approaches. STRUCTURE-FUNCTION ANALYSIS. Biosynthesis of MicroRNAs. Processing of MicroRNAs. MICRORNAs in DEVELOPMENT. Plants. C. elegans. Drosophila. Zebrafish. MICRORNAs AND CANCER. MICRORNAs AND VIRUSES. APPLICATIONS. Gene Regulation/Functional Genomics/Therapeutics.

O autorze

Rajesh K. Gaur, John J. Rossi