Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease

ISBN-13: 9781489986955 / Angielski / Miękka / 2014 / 443 str.

S. H. Fatemi

Opis

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

Recenzje

From the reviews:

"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. ... The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. ... This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody's Review Service, July, 2009)

"The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. ... The book consists of 28 chapters presented by international group of experts. ... book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders." (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)

Spis treści

The Reelin Gene and Its Functions in Brain Development Cheng-Chiu Huang, MS Gabriella D’Arcangelo, PhD* Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview Dr. Hans H. Bock* Prof. Dr. Joachim Herz Chemistry of Reelin Yves Jossin, PhD* The C-terminal region of Reelin: structure and function Mitsuharu Hattori, PhD* Crystal Structure of Reelin Repeats Junichi Takagi, PhD* Comparative Anatomy and Evolutionary Roles of Reelin Gundela Meyer, MD, PhD* Reelin / Dab1 Signaling in the Developing Cerebral Cortex Eric C. Olson, PhD* Christopher A. Walsh, MD, PhD Ultrastructural Localization of Reelin Rosalinda C. Roberts, PhD* Emma Perez-Costas, PhD Reelin and Cyclin-Dependent Kinase 5 Toshio Ohshima, MD, PhD* Reelin and the Cerebellum Robert F. Hevner, MD, PhD* Reelin and Radial Glial Cells Eckart Forster, PhD Shanting Zhao, MD Michael Frotscher, MD* Reelin and Cognition Shenfeng Qiu, PhD Edwin John Weeber, PhD* Protein Kinases and Signaling Pathways that are Activated by Reelin Jonathan A. Cooper, PhD* Nathaniel S. Allen, BS Libing Feng, PhD The Relationship of Oxytocin and Reelin in the Brain George D. Pappas, PhD* C. Sue Carter, PhD Reelin and Thyroid Hormone Manuel Alvarez-Dolado, PhD* A Tale of Two Genes: Reelin and BDNF Thomas Ringstedt, PhD* Reelin, Liver, and Lymphatics BrigitteSamama, PhD* Nelly Boehm, MD, PhD Reelin and Cajal-Retzius Cells Jean-Marc Mienville, PhD* Reelin and Odontogenesis Francoise Bleicher* Henry Magloire Marie-Lise Couble Jean-Christophe Maurin Homozygous and Heterozygous Reeler Mouse Mutants Patricia Tueting, PhD* Graziano Pinna, PhD Erminio Costa, MD Reelin and Lissencephaly Elena Parrini, PhD Renzo Guerrini, MD* The Role of Reelin in Etiology and Treatment of Psychiatric Disorders S. Hossein Fatemi, MD, PhD* Teri J. Reutiman, BA Timothy D. Folsom, MS Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia Erminio Costa, MD* Ying Chen, PhD Erbo Dong PhD Dennis R. Grayson, PhD Alessandro Guidotti, MD Marin Veldic, MD Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder Hamid Mostafavi Abdolmaleky, MD* Cassandra L. Smith PhD Jin-Rong Zhou, PhD Sam Thiagalingam, PhD Reelin Gene Polymorphisms in Autistic Disorder Carla Lintas PhD Antonio Maria Persico, MD* Alzheimer’s and Reelin Arancha Botella-Lopez, BS Javier Saez-Valero, PhD* Reelin and Stroke Kunlin Jin, MD, PhD* Reelin and Pancreatic Cancer Kimberly Walter, BS Michael Goggins, MD*

Blurb

Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.