Receptor Tyrosine Kinases: Family and Subfamilies

ISBN-13: 9783319353975 / Angielski / Miękka / 2016 / 878 str.

Deric L. Wheeler; Yosef Yarden

Recenzje

"An in depth study of the RTK families in 19 chapters. ... Clearly written and with extensive references after each chapter. For endocrinologists, molecular biologists and oncologists." (Pediatric Endocrinology Reviews (PER), Vol. 13 (3), March, 2016)

Spis treści

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase (RTK) Family.- The TAM Receptor Family.- DDR Receptor Tyrosine Kinase Family.- EGFR/ERBB Receptor Tyrosine Kinase Family.- Eph Receptor Tyrosine Kinase Family.- Receptor Tyrosine Kinase textbook – Fibroblast Growth Factor Receptor (FGFR).- Insulin/IGF1 Receptors (INSR/IGF1R) Family.- MET Receptor Tyrosine Kinase Family.- MuSK Receptor Family.- The PDGFR Receptor Family.- PTK7 Receptor Tyrosine Kinase Family.- RET Receptor Tyrosine Kinase.- ROR Receptor Tyrosine Kinase Family.- ROS1 Receptor Tyrosine Kinase.- The RYK Receptor Tyrosine Kinase Subfamily.- TIE Receptor Tyrosine Kinase Family.- TRK Receptor Family.- The VEGF Family of Ligands and Receptors.- NOK Receptor Tyrosine Kinase Family.

O autorze

Dr. Deric Wheeler received an M.S. in pathology from the University of Iowa and a Ph.D. in Cancer Biology from the University of Wisconsin. He conducted his postdoctoral training at the Fred Hutchinson Cancer Research Center in Seattle, WA, and at the University of Wisconsin School of Medicine and Public Health in Madison, where he eventually transitioned to faculty as an assistant professor in the department of human oncology. Dr. Wheeler’s lab research centers on resistance to molecular targeting agents and the role of subcellular localization of receptor tyrosine kinases and their roles in oncogenesis.

Dr. Yosef Yarden received a Ph.D. in Molecular Biology from the Weizmann Institute of Science in Rehovot, Israel. He completed postdoctoral training at Genentech, Inc. in San Francisco and at the Massachusetts Institute of Technology in Cambridge. He returned to the Weizmann Institute of Science first as an assistant professor and then later as a full professor. His past administrative responsibilities at the Weizmann Institute include Dean of the Faculty of Biology, Vice-President for Academic Affairs, Director of the M.D. Moross Institute for Cancer Research, and Dean of the Feinberg Graduate School. Dr. Yarden’s lab research centers on the roles played by growth factors and receptor tyrosine kinases in tumor progression.

Blurb

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Family and Subfamilies systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the fifty-eight RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, which refers to specific subfamilies of RTKs, along with their unique landmarks.