Recent Advances in Chiral Separations

ISBN-13: 9781468482843 / Angielski / Miękka / 2012 / 230 str.

Derek Stevenson; I. D. Wilson

Opis

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989. Like the preceding meeting, it was jointly organised by the Chromatographic Society and the Robens Institute of the University of Surrey in response to the continued interest in this area of separation science. Of particular interest to the organisers was the very clear change in the nature of the delegates attending this second symposium as compared with the first. At the previous meeting the majority of the delegates were composed of chromatographers with problems in the area of chiral separations who were keen to learn as much as possible about these techniques from the handful of recognised experts in this area. In this second symposium the divide between expert and novice was much less apparent, with the latter providing many interesting and useful contributions to the scientific programme in termt; of both oral and poster presentations.

Spis treści

A Regulatory View of the Importance of Chiral Discrimination.- Is There a Rational Basis for the Selection and/or Design of Chiral Stationary Phases for High-Performance Liquid Chromatography?.- Chromatographic Chiral Separations on Immobilised Proteins: Does High-Performance Liquid Chromatography Mirror Nature?.- Some Examples of Chiral High-Performance Liquid Chromatographic Resolution in the Pharmaceutical Industry.- The Design of Chiral Separations for ?-Blocker Drugs on Pirkle High-Performance Liquid Chromatography Phases Using Achiral Derivatisation.- The Use of Reciprocal Interaction in the Design of Pyrethroid Specific Chiral Stationary Phases.- Stereochemical Analysis of Chiral Alcohol, Epoxide and Sulphoxide Metabolites by Chiral Stationary Phase High-Performance Liquid Chromatography.- Separation and Assignment of the Stereoisomers of ?-(p-Chlorophenyl) Glutamic Acid by Ligand Exchange Chromatography.- Direct Separation of Mefloquine Enantiomers by Liquid Chromatography on a Urea-Linked Chiral Stationary Phase.- An Evaluation of Some Chiral Stationary Phases for the Separation of ?-Blocker Drugs.- Synthesis of Aminoalcohol and Oxazolidone Chiral Stationary Phases for High-Performance Liquid Chromatography.- The Role of Mobile Phase Additives in Developing and Optimising Separations of Water-Soluble Enantiomers by High-Performance Liquid Chromatography.- Chiral Ion-Pair Chromatography of Novel Basic Antihypertensive Agents.- Optimisation of Chiral Separation of Doxazosin Enantiomers by High-Performance Liquid Chromatography on a Second Generation al-Acid Glycoprotein Column.- Attempts to Quantify the Effect of Selected Structural Parameters on the Separation of Some N-Arylthiazoline-2-thione and N-Arylthiazolin-2-one Atropisomers on the Chiral Stationary Phase, Cellulose Triacetate (CTAl).- Temperature Effects on High-Performance Liquid Chromatographic Enantiomeric Resolution Using Chiral Stationary Phases Containing trans- 1,2-Diaminocyclohexane Derivatives.- Enantiomer Separation on Dissolved Cyclodextrin Derivatives by High-Resolution Gas Chromatography: Thermodynamic Data of Chiral Recognition.- Chiral Chromatography on the Process Scale.- A Diode Laser Polarimetric High-Performance Liquid Chromatography Detector and Applications to Enantiomeric Purity Determinations and Enantioselective Reactions.- High-Performance Thin-Layer Chromatography: A Quantitative Technique for Enantiomer Separation.- Chiral Separations by Thin-Layer Chromatography.- Appendix 1 — Abstracts.- Appendix 2 — Chiral Chromatography Literature 1988–1989.- Authors to Papers Cross-Reference.- Compounds to Papers Cross-Reference.- Author Index.- Compound Index.