Raloxifene immediate release tablet for post-menopausal osteoporosis

ISBN-13: 9786203194142 / Angielski / Miękka / 160 str.

Binapani Barik; Prafulla Kumar Sahu; Dinesh Kumar Sharma

Opis

The book involves a research work towards developing a formulation of anti-osteoporotic drug, which has in-vitro dissolution profile similar to that of the Innovators' formulation. The patents for dosage form of Raloxifene will expire in late future. Hence, our target was to develop a dosage form as that of Innovator product to file an ANDA application. The present study involves the development of a non-infringing formula for an orally administrable immediate release tablet of the anti-osteoporotic drug with reproducible and robust process. The objectives of the research work included (i) formulation and optimization of the coated tablets of Raloxifene with the aid of design of experiment; (ii) enhance dissolution and evaluate release kinetics of drug from the formulation; (iii) comparison of dissolution profiles of developed formulation with innovator product.

O autorze

Barik, Binapani Dr. Prafulla Kumar Sahu, M.Pharm., Ph.D., is serving as Principal, School of Pharmacy, Centurion University of Technology & Management, India. Ms Binapani Barik, M.Pharm & Mr Dinesh Kumar Sharma, M.Pharm are working as faculties at School of Pharmacy. Dr. Sahu has fifteen years of experience in teaching and over fifty research papers to his credit.