RD Cell Line Study of New Complexes of Some Transition Metals

ISBN-13: 9783659142314 / Angielski / Miękka / 2012 / 144 str.

Carol Shakir; Mahasin Alias; Emad Yousif

Opis

A new ligand of dithiocarbamato derivative containing triazole ring and hydrazide group in it, have been synthesized in this work. The product was isolated, characterized, and studied by appropriate physical measurements i.e. FT-IR, UV-Vis spectroscopy and the elemental analysis C.H.N.S as well as melting point. The new ligand was used to prepare a number of transition metal complexes (heavy and light metals). Cytotoxicity effect of some complexes (heavy metals) (PtL, AuL, RhL, CuL & PdL) as well as ligand have evaluated against RD cell line by using four different concentrations (500, 250, 125& 62.5 µg/ml) respectively, and in three exposure times 24, 48 and 72 hrs and compared this cytotoxic effect with control positive Cis-Pt, the results showed the cytotoxic effects of new compounds on RD cell line depending on both concentration and time of exposure.

O autorze

born 1th August 1986, Baghdad, Iraq. B. Sc. of Chemistry from the College of Science for Women, University of Baghdad in 2008 and in 2012 obtained a master's degree in inorganic chemistry from the College itself. My research interests poured on the area of Bioinorganic Chemistry.