Psychiatric Genetics: Methods and Reviews

ISBN-13: 9781588290373 / Angielski / Twarda / 2002 / 268 str.

J.D. Charles J. Russo; Marion Leboyer; Frank Bellivier

Opis

This volume provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions. The best European and American specialists have given a thorough review on the advantages and disadvantages of genetic epidemiological methods, the way to choose a genetic marker or a clinical interview and how to ascertain patients, unaffected relatives and controls and what should be the criteria to include a case or a control. New phenotypic methods are described focusing on candidate symptom and endohenotype approaches. Examples coming from cognitive neurosciences, biochemistry, electrophysiology and brain imaging techniques are reviewed.

Recenzje

"...a valiant attempt to make sense of a substantial portion of the methodological aspects of research in psychiatric genetics. Students and senior investigators should both give serious consideration to this book's arguments and advice." - Genes, Brain and Behavior

"...provides a relatively succinct introduction to a range of issues relating to the filed of psychiatric genetics...would be an excellent book for a young researcher about to enter the field of psychiatric genetics and would enable him or her to obtain a rapid overview of methodological issues." - Journal of Medical Genetics

"...great for getting new ideas as well as suggestions for how to deal with practical research questions." - Psychological Medicine

"This book is very useful for students or psychiatrists interested in genetics and how it applies to psychiatric illness. It is one of few in the field to give a comprehensive review of the field." -Doody's Health Sciences Book Review Journal

"Marion Leboyer and Frank Bellivier have put together a very good review of the variety of methods and approaches previously used in this complex area of research and, for this reason, this book provides a useful text for someone entering the field of psychiatric genetics." -Human Genetics

Spis treści

Part I. Introduction Psychiatric Genetics: Overview on Achievements, Problems, Perspectives Wolfgang Maier Part II. Methods in Psychiatric Genetics: Advantages and Limits Analytical Methods Applied to Psychiatric Genetics Elena L. Grigorenko and David L. Pauls Genetic Markers in Psychiatric Genetics Thomas Bourgeron and Bruno Giros Clinical Assessment in Psychiatric Genetics Philip Gorwood Genetic Association Studies: Definition of Cases and Controls Frank Bellivier Part III. New Phenotypic Approaches Searching for Alternative Phenotypes in Psychiatric Genetics Marion Leboyer Intermediate Cognitive Phenotypes Associated with Schizophrenia Michael F. Egan and Terry E. Goldberg Biochemical Endophenotypes in Personality Disorders Antonia S. New and Larry J. Siever Electrophysiological Phenotypes Robert Freedman Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia Joseph H. Callicott and Daniel R. Weinberger Part IV. Conclusion Psychiatric Genetics: Future and Prospects Ming T. Tsuang, Levi Taylor, and Stephen V. Faraone Index

Blurb

Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed.
Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved.