Proteomics of Human Body Fluids: Principles, Methods, and Applications

ISBN-13: 9781617377006 / Angielski / Miękka / 2010 / 533 str.

Visith Thongboonkerd

Opis

Rapid growth of the proteomics field during the past twelve years has c- tributed to significant advances in science. To date, proteomic technologies have been widely applied to examining various kinds of biological materials. Clinical proteomics is the concept of using proteomic techniques to evaluate the proteomes in clinical samples for biomarker discovery and for better understa- ing of normal physiology and pathogenic mechanisms of human diseases. Tra- lating the proteomic information to clinical practice may lead to the ultimate goals of earlier diagnosis, improved therapeutic outcome and successful prev- tion of diseases. Human body fluids are produced, secreted, and/or excreted from various tissues or organs. Major compositions of body fluids are water, organic s- stances and inorganic compounds. These compositions vary in each body fluid, making one s function different from the others. Analyses of protein com- nents in individual fluids would increase current knowledge on the biology and physiology of various organ systems, and on the pathophysiology of diseases, which cause alterations in protein production, secretion, and/or excretion from the affected tissues or organs into the body fluids. Additionally, human body fluids are the main targets and valuable sources for biomarker discovery. As the high-throughput capability and applicability of proteomics for analyzing proteins in the body fluids have been already proven, these desires are most likely achievable by using proteomic technologies."

Spis treści

PROTEOMICS OF HUMAN BODY FLUIDS: Principles, Methods, and Applications' EDITOR: VISITH THONGBOONKERD, MD, FRCPT Table of Contents Preface Part I: Principles of Proteomics Applied to Human Body Fluids 1. Proteomic Strategies for Analyzing Body Fluids Sung-Min Ahn Richard J. Simpson* 2. Sample Preparation of Body Fluids for Proteomics Analysis Natalia Govorukhina Rainer Bischoff* 3. Multiplexed Immunoassays for Protein Profiling in Human Body Fluids Silke Wittemann Dominic P. Eisinger Laurie L. Stephen Thomas O. Joos* 4. Deciphering the Hieroglyphics of Functional Proteomics Using Small Molecule Probes Wayne F. Patton* 5. Modification-Specific Proteomic Analysis of Glycoproteins in Human Body Fluids by Mass Spectrometry Jakob Bunkenborg Per Hägglund Ole N. Jensen* 6. Plasma Proteome Database Malabika Sarker G. Hanumanthu Akhilesh Pandey* 7. 2-D PAGE Databases for Proteins in Human Body Fluids Christine Hoogland* Khaled Mostaguir Jean-Charles Sanchez Denis F. Hochstrasser Ron D. Appel 8. Bioinformatics and Experimental Design for Biomarker Discovery Marc R. Wilkins* Sybille M. N. Hunt 9. Integrative Omics, Pharmacoproteomics and Human Body Fluids K. K. Jain* Part II: Proteomic Analysis of Specific Types of Human Body Fluids: Methods, Findings, Applications, Perspectives, and Future Directions 10. The Human Plasma Proteome Gilbert S. Omenn* Raji Menon Marcin Adamski Thomas Blackwell Brian B. Haab Weimin Gao David J. States 11. Proteomics of Human Urine Visith Thongboonkerd* Pedro R. Cutillas Robert J. Unwin Stefan Schaub Peter Nickerson Marion Haubitz Harald Mischak Dobrin Nedelkov Urban Kiernan Randall W. Nelson 12. Proteomics of Human Cerebrospinal Fluid Margareta Ramström Jonas Bergquist* 13. Proteomics of Pleural Effusion Joost Hegmans* Annabrita Hemmes Bart N. Lambrecht 14. Proteomics of Bronchoalveolar Lavage Fluid and Sputum Ruddy Wattiez* Olivier Michel Paul Falmagne 15. Proteomics of Sinusitis Nasal Lavage Fluid Begona Casado*,# Simona Viglio James N. Baraniuk 16. Proteomics of Human Saliva Francisco M. L. Amado* Rui M. P. Vitorino Maria J. C. Lobo Pedro M. D. N. Domingues 17. Proteomics of Human Pancreatic Juice Mads Grønborg Anirban Maitra Akhilesh Pandey* 18. Proteomics of Human Bile Troels Z. Kristiansen Anirban Maitra Akhilesh Pandey* 19. Proteomics of Amniotic Fluid David Crettaz Lynne Thadikkaran Denis Gallot Pierre-Alain Queloz Vincent Sapin Joël S. Rossier Patrick Hohlfled Jean-Daniel Tissot* 20. Proteomics of Human Milk Amedeo Conti* Maria G. Giuffrida Maria Cavaletto 21. Proteomics of Nipple Aspirate Fluid in Non-Lactating Women Edward R. Sauter* 22. Proteomics of Seminal Fluid Benjamin Solomon Mark W. Duncan* 23. Proteomics of Vitreous Fluid Atsushi Minamoto* Ken Yamane Tomoko Yokoyama 24. Proteomics of Human Dialysate and Ultrafiltrate Fluids Yielded by Renal Replacement Therapy Michael Walden Stefan Wittke Harald Mischak Raymond C. Vanholder For the European Uremic Toxin Work Group (EUTox)

Blurb

The recent development of proteomics studies into clinical examinations of proteomics promises to lead toward the ultimate goals of earlier diagnosis, improved therapeutic outcome and successful prevention of diseases.  In Proteomics of Human Body Fluids: Principles, Methods, and Applications,  top experts provide the premier collection of proteomics applications designed to analyze various human body fluids.  Beginning with basic principles and strategies then exploring methodologies, recent findings, and clinical applications, this authoritative volume covers its subject in great detail from many angles.

Comprehensive and extensive, Proteomics of Human Body Fluids: Principles, Methods, and Applications is an ideal reference for all scientists interested in this vital, growing field of study.