Protein Targeting, Transport, and Translocation

ISBN-13: 9780122007316 / Angielski / Twarda / 2002 / 336 str.

Gunnar Von Heijne; Ross E. Dalbey; Gunnar Von Heijne

Opis

Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields.

• Basic principles and techniques
• Targeting adn sorting sequences
• Protein export in bacteria
• Membrane protein integration into ER and bacterial membranes
• Protein translocation across the ER
• Disulfide bond formation in prokaryotes and eukaryotes
• Quality control in the export pathway
• Import of proteins into organelles
• The secretory pathway
• Vesicular transport
• Spectacular color throughout

Recenzje

"...Dalbey et al. have summed up what has happened so far in a rapidly moving field of modern cellular biochemistry." --EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, 2003

"Overall this book provides good summaries of what we know about how proteins are moved between intracellular compartments and how we have studied this problem. Students or anyone wanting to know more about protein trafficking, particularly protein translocation across membranes, will find it a useful guide." --CELL, 2002

Spis treści

Methods in Protein Targeting, Translocation and Transport
Targeting Sequences
Protein Export in Bacteria
Protein Sorting at the Membrane of the Endoplasmic Reticulum
Membrane Protein Insertion into Bacteial Membranes and Endoplasmic Reticulum
Disulfide Bond Formation in Prokaryotes and Eukaryotes
The Unfolded Protein Response
Protein Quality Control in the Export Pathway: The Endoplasmic Reticulum and its Cytoplasmic Proteasome Connection
Translocation of Proteins into Mitochondria
The Import and Sorting of Protein into Chloroplasts
Import of Proteins into Peroxisomes
Nucleocytoplasmic Transport
Protein Transport to the Yeast Vacuole
The Secretory Pathway
Vesicular Transport
Conclusion/Perspective