Protein Structure and Function

ISBN-13: 9780878936632 / Angielski / Miękka / 2003 / 180 str.

Gregory A. Petsko (Brandeis University);Dagmar Ringe (Brandeis University)

Opis

Protein Structure and Function is an introduction for postgenomic biologists to the structural basis for the biological activities of proteins, with special emphasis on the interpretation of gene sequence in terms of protein function. Early chapters discuss the determinants of folding and stability and of secondary, tertiary and quaternary structure, the universe of protein folds, and superfamilies and motifs in the analysis of protein function, as well as the basic principles of protein function, with major sections on ligand binding and enzyme catalysis. Later chapters describe the regulation of protein function and how proteins work as switches, machines and motors, and discuss the contribution of comparative structural analysis to the understanding of the relationship between sequence, structure and function. The book ends with a short chapter on how the structures of proteins are determined.

Recenzje

I have not encountered a book better than this one for students interested in learning more about structure-function relationships in proteins."

O autorze

Gregory A. Petsko studied chemistry and classics as an undergraduate at Princeton University before going to Oxford as a Rhodes scholar to work for his Ph.D. with David Phillips. He then pursued his interest in the mechanism of enzyme catalysis at the Massachusetts Institute of Technology, where he taught courses in chemistry and detective fiction. Currently the Director of the Rosenstiel Center at Brandeis, he has extended his research interests to include the use of yeast genetics to study the unfolded protein response pathway, and the mechanism of action of the ABC transporter proteins. Dagmar Ringe graduated in chemistry from Barnard College, Columbia, and took her Ph.D. in bioorganic chemistry from Boston University. She then pursued her research interest in the study of enzyme catalysis by X-ray crystallography at the Massachusetts Institute of Technology before moving to Brandeis, where she is Professor of Biochemistry and Chemistry. The principal focus of Dr. Ringe's research is structure-function relationships in enzymes of particular industrial and pharmaceutical importance.