Protease Inhibitors as Cancer Chemopreventive Agents

ISBN-13: 9780306443909 / Angielski / Twarda / 1993 / 315 str.

Walter Troll; A. R. Kennedy; W. Troll

Opis

Protease inhibitors (PIs), which are widely distributed in plants and animals and have a variety of functions, interfere with cancer development in a number of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human c

Spis treści

The Epidemiological Approach to the Study of Protease Inhibitors (Fontham, Correa). In vitro Studies of Anticarcinogenic Protease Inhibitors (Kennedy). Discovery and Background of the BowmanBirk Protease Inhibitors (Bowman). Antigenicity of Soybean Protease Inhibitors (Bandon et al.). Low Molecular Weight Protease Inhibitors of Microbial Origin (Umezawa et al.). Protease Inhibitor Synthesis by MCF7 Breast Cancer Cells (Finlay et al.). Analysis of StructurActivity Relationships of the BowmanBirk Inhibitor of Serine Proteases (Flecker). Prevention of Cancer by Vitamin B 3 (Troll). Approaches to Studying the Target Enzymes of Anticarcinogenic Protease Inhibitors (Billings). Anticarcinogenic Activities of Naturally Occuring Cysteine Protease Inhibitors (Colella et al.). Cell Membrane Enzymes Containing ChymotrypsinLike Activity (Yavelow et al.). The Role of Active Oxygen Species in Biological Damage and the Effect of Some Chemopreventative Agents (Frenkel). 6 additional articles. Index.