Proceedings of the Fourth International Symposium on Cyclodextrins: Munich, West Germany, April 20-22, 1988

ISBN-13: 9780792300007 / Angielski / Twarda / 1988 / 576 str.

J. Szejtli; O. Huber

Opis

The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins. This Symposium - held in September 1981 in Budapest, with more than 200 participants from 17 countries - proved to be very succesfull in every respect, therefore it has been accepted unanimously to organize the lInd CD-Symposium in 1984, in Tokyo. (The Budapest-Symposium got posteriorly the "First" adjective). The IInd Symposium was held together with the III. Int. Symposium on Chlatrate Compounds and Molecular Inclusion Phenomena. The IIIrd CD-Symposium also was held as a Joint Symposium, with the IVth. Chlatrate Symposium in Lancaster, U. K.,1986. The limited time however showed, that such a broad field - from calixarenes to zeolites - can not be managed efficiently. Therefore the International Organizing Committee voted for separation of two Symposia in the future. The IVth Int. CD-Symposium was held in the Munich, in April 1988, and the Vth Chlatrate Symposium (called already Vth Int. Symposium on Inclusion Phenomena and Molecular Recognition) was held in Alabama, Sept. 1988. In Munich 220 participants from 21 countries attended 32 verbal lectures and 54 posters. This volume contains the submitted 71 manuscripts of the IVth Cyclodextrin Symposium.

Spis treści

Introductory Remarks.- 1. Chemistry, Enzymology and Production of Cyclodextrins.- 1.1. Enzymology and Molecular Genetics of CD-Forming Enzymes.- 1.2. Studies on The Reaction Mechanism of Cyclodextrin Glyco-Syl- Transferases: Subsite Analysis.- 1.3. Cultural Characteristics of a Cyclomaltodextrin Glucano-Transferase-Producing Alkalophilic Bacillus SP..- 1.4. Use of Cyclohexane in The Production of Pure Alpha- And Beta-Cyclodextrins.- 1.5. Cyclodextrins From Potato Starch. Recent Developments..- 1.6. Production of Cyclodextrins Using Immobilized Enzymes..- 1.7. Immobilization of Pullulanase And Succesive Synthesis of Branched Cyclodextrins by Immobilized Pullulanase..- 1.8. The Acid Hydrolysis of Cyclodextrins and Linear Oligosaccharides: A Comparative Study..- 1.9. Isolation and Purification of Gamma-Cyclodextrin by Affinity Chromatography.- 1.10. Cloning and Nucleotide Sequence of a Cyclodextrin Glycosyltransferase Gene From The Alkalophilic Bacillus 1–1..- 1.11. Expression of The Gene For Cyclodextrin-Glycosyl-Transferase From Klebsiella In E. Coli.- 1.12. Method Development For Economic Production of Cyclodextrins By Means Of Ternary Complex Formation.- 1.13. Selective Complexing Agents For The Production Of ?-Cyclodextrin.- 2. Cyclodextrin Derivatives.- 2.1. Preparation and NMR Study of Maltooligomers.- 2.2. A Chemically Modified Cyclodextrin.- 2.3. Methylation of Cyclodextrins Via Phase- Transfer Catalysis.- 2.4. Environmental Effects on Molecular Properties of Organic Compounds. III. Cyclodextrins With a Schiff-Base Moiety..- 2.5. The Inclusion Properties of 6-Linked ?-Cyclodextrin 1-Thio- ?-D-Glycosides..- 2.6. Selective Multiple 6-Substitution in Cyclodextrin by Hydrophobic and Hydrophilic Groups..- 2.7. Inclusion Properties of Hydrophobic Derivatives of Cyclodextrins (CDs).- 2.8. Cyclodextrin-Cellulose Copolymers.- 2.9. Characterization of Cyclodextrin Derivatives by The Reductive-Cleavage Method.- 2.10. Modified Cyclodextrins; Substitution of 03 and Complexation of Metals.- 3. Chemical and Physical Properties of CD-Complexes.- 3.1. Chemical and Physical Studies On Cyclodextrin Inclusion Compounds.- 3.2. Preparation and 13C-NMR Identification of Solid Cyclodextrin Inclusion Compounds..- 3.3. Inclusion Compounds in Water. Interaction of ?-Cyclodextrin With Urea Derivatives at 25°C..- 3.4. Dynamic Aspects of Molecular Inclusion Reactions by Cyclo-Dextrins.- 3.5. Interaction of Cyclodextrins With Glycolipids. 1H-NMR Studies.- 3.6. Chemically-Modified Cyclodextrins As Second Sphere Ligands for Transition Metal Complexes.- 3.7. Some Interesting Aspects in 1H-NMR Spectroscopy by Cyclodextrin Complexation.- 3.8. Molecular Inclusion Reaction of Charged Cyclodextrins.- 3.9. Inclusion Complexes of Naphthols With Cyclodextrins in Aqueous Solution. A 1H-NMR Study.- 3.10. IR-Spectroscopic Measurement of the P-Nitrophenol ?-Cyclo-Dextrin Equilibrium in Aqueous Solution.- 3.11. Complexes of Insoluble Cyclodextrin Polymers.- 3.12. Methods For Characterization of The Wettability of Cyclodextrin Complexes.- 3.13. Detailed Structure of an ?-Cyclodextrin-Cyclopentanone Clathrate by Neutron Diffraction.- 3.14. Influence of Ethanol on The Complexation of Isometric Chloronitrobenzenes By ?-Cyclodextrin.- 3.15. Characterisation of ?-Cyclodextrin Complexes.- 4. Cyclodextrins in Pharmaceuticals.- 4.1. New Trends in Pharmaceutical Applications of Cyclodextrin Inclusion Compounds.- 4.2. Menadione Inclusion Compounds With Mixtures of Natural Cyclodextrins.- 4.3. Interactions Between Cyclodextrins and Some Antimycotic Imidazole Derivatives: Studies on Solubility and Antimicrobal Activity..- 4.4. Increasing The Solubility Characteristics of Iomeglamic Acid With ?-Cyclodextrin.- 4.5. The Inclusion Complex of Tolbutamide With Maltosyl (G2) -?-Cyclo-Dextrin in Aqueous Solution and in the Solid State.- 4.6. Complexation of Polyene Antibiotics With ?-Cyclodextrin.- 4.7. The Effect of Cyclodextrins on the Mitomycin Stability in Acidic Aqueous Media.- 4.8. Assessment of the Stoichiometry of a Vinburnine and Gamma-Cyclodextrin Complex by Microcalorimetry.- 4.9. Molecular Encapsulation Of Retinoic Acid by ?-Cyclodextrin, Characterization of the Inclusion Compound.- 4.10. Solubility Enhancement of Ipriflavone by Cyclodextrin Complexation.- 4.11. The Effect of Beta-Cyclodextrin Complexation on Plasma Levels of Ipriflavone and Its Main Metabolites.- 4.12. The Comparison of Absorption, Distribution and Elimination of Ipriflavone-14C and Ipriflavone- 14C-Beta-Cyclodextrin Inclusion Complex.- 4.13. The Influence of Inclusion by Cyclodextrins on Absorption Kinetics of Dantrolene in the Rat.- 4.14. Improvement on Photostability of Several Essential Oils and Menadione by Natural Cyclodextrins.- 4.15. Bitterness Reduction With Beta-Cyclodextrin.- 5. Cyclodextrin Derivatives in Pharmaceuticals.- 5.1. Cyclodextrin Derivatives For Solubilisation, Stabilisation, and Absorption of Drugs.- 5.2. Biomedical Uses of Amorphous Water Soluble Derivatives of Cyclodextrins.- 5.3. Highly Soluble ?-Cyclodextrin Derivatives, A Comparative Study.- 5.4. Water Soluble Complexes of a Brain-Targeted Drug Delivery System.- 5.5. Pharmacokinetics of Dimethyl-Beta- Cyclodextrin in Rats.- 5.6. Percutaneous Absorption of Heptakis-(2,6-DI-0-14C- Methyl)- ?-Cyclodextrin in Rats.- 5.7. Investigation of the Hemolytic Effect of the Cyclo-Dextrin Derivatives.- 5.8. Determination of Hydroxypropyl- ?-Cyclodextrin in Plasma and Urin by Size Exclusion Chromatography With Post Column Complexation.- 6. CDs in Catalysis and Analytical Chemistry.- 6.1. Cyclodextrins in Analytical Chemistry.- 6.2. Cyclodextrins in Chromatography and Isotac-Hophoresis.- 6.3. Enantioselective Capillary Gas Chromatography With Modified Cyclodextrins as Chiral Stationary Phases.- 6.4. HPLC of Chloramphenicol and Some of its Synthetic Intermediates on a Cyclodextrin-Bonded Chiral Stationary Phase.- 6.5. Gaschromatographic Capillary Columns With Cyclodextrins as Stationary Phases.- 6.6. Fluorescence Studies of Cyclodextrin Complexes.- 6.7. Immobilized Cyclodextrins for Affinity Chromatography.- 6.8. Gelchromatographic Separation of Proteins on Cyclodextrin Bead Polymers.- 6.9. ?-Cyclodextrin in Optical Resolution of Chiral Sulphinyl Derivatives.- 6.10. Catalytic Activity of Artificial Hydrolases Using Modified Cyclodextrins.- 6.11. Functionalized Cyclodextrins as Oxydo-Reductasic Enzyme Models.- 6.12. Selective Reductions of CD Complexed Terpenes.- 6.13. Reactions in the Presence of Cyclodextrins.- 7. Cyclodextrins in Foods and Agriculture.- 7.1. Application of Cyclodextrins to Foods, Toiletries and Other Products in Japan.- 7.2. Long Term Storage Stability Studies on Flavour- ?-Cyclo-Dextrin Complexes.- 7.3. Application of ?-Cyclodextrin in Meat Industry.- 7.4. Effect of Cyclodextrin and Glycerolmonostearate on Starch Gelatinization.- 7.5. Fungicidal Activity of Benomyl in Presence of ?-Cyclo-Dextrin.