Preclinical MRI of the Kidney: Methods and Protocols

ISBN-13: 9781071609774 / Angielski / Twarda / 2021 / 725 str.

Andreas Pohlmann

Spis treści

Preface…
Table of Contents…
Contributing Authors…

Part I Introduction

1. Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies
Andreas Pohlmann, Susan J. Back, Andrea Fekete, Iris Friedli, Stefanie Hectors, Neil Peter Jerome, Min-Chi Ku, Dario Livio Longo, Martin Meier, Jason M. Millward, João S. Periquito, Erdmann Seeliger, Suraj D. Serai, Sonia Waiczies, Steven Sourbron, Christoffer Laustsen, and Thoralf Niendorf

Part II Animal Models, Preparation, Monitoring, and Physiological Interventions

2. Animal Models of Renal Pathophysiology and Disease
Adam Hosszu, Tamas Kaucsar, Erdmann Seeliger, and Andrea Fekete

3. Preparation and Monitoring of Small Animals in Renal MRI
Tamas Kaucsar, Adam Hosszu, Erdmann Seeliger, Henning M. Reimann, and Andrea Fekete

4. Reversible (Patho-)Physiologically Relevant Test Interventions: Rationale and Examples 
Kathleen Cantow, Mechthild Ladwig-Wiegard, Bert Flemming, Andrea Fekete, Adam Hosszu, Erdmann Seeliger

5. Preparation of Ex Vivo Rodent Phantoms for Developing, Testing, and Training MR Imaging of the Kidney and Other Organs 
Jason M. Millward, João S. Periquito, Paula Ramos Delgado, Christian Prinz, Thoralf Niendorf, and Sonia Waiczies

Part III Basic Concepts of Measurement Techniques

6. Quantitative Assessment of Renal Perfusion and Oxygenation by Invasive Probes: Basic Concepts
Kathleen Cantow, Roger G. Evans, Dirk Grosenick, Thomas Gladytz, Thoralf Niendorf, Bert Flemming, and Erdmann Seeliger

7. Ultrasound and Photoacoustic Imaging of the Kidney: Basic Concepts and Protocols
Sandra Meyer, Dieter Fuchs, and  Martin Meier

8. Hardware Considerations for Preclinical Magnetic Resonance of the Kidney
Paula Ramos Delgado, Ekkehard Küstermann, André Kühne, Jason M. Millward, Thoralf Niendorf, Andreas Pohlmann, and Martin Meier

9. MRI Mapping of Renal T1: Basic Concept
Stefanie Hectors, Sabrina Doblas, Philippe Garteiser, Gwenaël Pagé, Bernard E. Van Beers, John C. Waterton,  and Octavia Bane

10. MRI Mapping of the Blood Oxygenation Sensitive Parameter T2* in the Kidney: Basic Concept
Lu-Ping Li, Bradley Hack, Erdmann Seeliger, and Pottumarthi V. Prasad

11. Renal Diffusion Weighted Imaging (DWI) for Apparent Diffusion Coefficient (ADC), Intra Voxel Incoherent Motion (IVIM), and Diffusion Tensor Imaging (DTI): Basic Concept
Neil Peter Jerome, Anna Caroli, and Alexandra Ljimani

12. Dynamic Contrast Enhancement (DCE)-MRI Derived Renal Perfusion and Filtration: Basic Concepts
Michael Pedersen, Pietro Irrera, Walter Dastrù, Frank G. Zöllner, Kevin M. Bennett, Scott C. Beeman, G. Larry Bretthorst, Joel R. Garbow, and Dario Livio Longo

13. Non-Invasive Renal Perfusion Measurement Using Arterial Spin Labelling (ASL) MRI: Basic Concept
Min-Chi Ku, María A. Fernández-Seara, Frank Kober, and Thoralf Niendorf

14. Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST)-MRI: Basic Concepts
Dario Livio Longo, Pietro Irrera, Lorena Consolino, Phillip Zhe Sun, and Michael T. McMahon

15. Sodium (23Na) MRI of the Kidney: Basic Concept
James T. Grist, Esben Søvsø Hansen, Frank G. Zöllner, and Christoffer Laustsen

16. Hyperpolarized Carbon (13C) MRI of the Kidneys: Basic Concepts
Cornelius von Morze, Galen D. Reed, Zhen J. Wang, Michael A. Ohliger, and Christoffer Laustsen

17. Functional Imaging Using Fluorine (19F) MR Methods: Basic Concepts
Sonia Waiczies, Christian Prinz, Ludger Starke, Jason M. Millward, Paula Ramos Delgado, Jens Rosenberg, Marc Nazaré, Helmar Waiczies, Andreas Pohlmann, and Thoralf Niendorf

18. MR Elastography of the Abdomen: Basic Concepts
Suraj D. Serai and Meng Yin

Part IV Experimental Protocols

19. Monitoring Renal Hemodynamics and Oxygenation by Invasive Probes: Experimental Protocol
Kathleen Cantow, Mechthild Ladwig-Wiegard, Bert Flemming, Andreas Pohlmann, Thoralf Niendorf, and Erdmann Seeliger

20. Essential Practical Steps for MRI of the Kidney in Experimental Research 
Andreas Pohlmann, João S. Periquito, and Thoralf Niendorf

21. Assessment of Renal Volume with MRI: Experimental Protocol
Andreas Müller and Martin Meier

22. Experimental Protocols for MRI Mapping of Renal T1
Philippe Garteiser, Octavia Bane, Sabrina Doblas, Iris Friedli, Stefanie Hectors, Gwenaël Pagé, Bernard E. Van Beers, and John C. Waterton

23. Experimental Protocols for MRI Mapping of the Blood Oxygenation Sensitive Parameters T2* and T2 in the Kidney
Andreas Pohlmann, Kaixuan Zhao, Sean B. Fain, Pottumarthi V. Prasad, and Thoralf Niendorf

24. Renal MRI Diffusion: Experimental Protocol 
João S. Periquito, Martin Meier, Thoralf Niendorf, Andreas Pohlmann, and Neil Peter Jerome

25. Dynamic Contrast Enhanced (DCE)-MRI Derived Renal Perfusion and Filtration: Experimental Protocol
Pietro Irrera, Lorena Consolino, Walter Dastrù, Michael Pedersen, Frank G. Zöllner, Dario Livio Longo

26. Renal Blood Flow Using Arterial Spin Labeling (ASL)-MRI: Experimental Protocol and Principles
 Kai-Hsiang Chuang, Martin Meier, María A. Fernández-Seara, Frank Kober, and Min-Chi Ku

27. Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST)-MRI: Experimental Protocol
Kowsalya Devi Pavuluri, Lorena Consolino, Dario Livio Longo, Pietro Irrera, Phillip Zhe Sun, and Michael T. McMahon

28. Sodium (23Na) MRI of the Kidney: Experimental Protocol
James T. Grist, Esben Søvsø Hansen, Frank G. Zöllner, and Christoffer Laustsen

29. Hyperpolarized Carbon (13C) MRI of the Kidney: Experimental Protocol 
Christoffer Laustsen, Cornelius von Morze, and Galen Reed

30. Fluorine (19F) MRI for Assessing Inflammatory Cells in the Kidney: Experimental Protocol
Min-Chi Ku, Adrian Schreiber, Paula Ramos Delgado, Philipp Boehm-Sturm, Ralph Kettritz, Thoralf Niendorf, Andreas Pohlmann, and Sonia Waiczies

31. Fluorine (19F) MRI to Measure Renal Oxygen Tension and Blood Volume: Experimental Protocol 
Lingzhi Hu, Hua Pan, and Samuel A. Wickline

32. MR Elastography of the Abdomen: Experimental Protocols
Suraj D. Serai and Meng Yin

Part V Protocols for Advanced Analyses

33. Subsegmentation of the Kidney in Experimental MR Images Using Morphology-Based Regions-of-Interest or Multiple-Layer Concentric Objects
Leili Riazy, Bastien Milani, João S. Periquito, Kathleen Cantow, Thoralf Niendorf, Menno Pruijm, Erdmann Seeliger, and Andreas Pohlmann

34. De-Noising for Improved Parametric MRI of the Kidney: Protocol for Non-Local Means Filtering 
Ludger Starke, Karsten Tabelow, Thoralf Niendorf, and Andreas Pohlmann

35. Analysis Protocols for MRI Mapping of Renal T1
Philippe Garteiser, Gwenaël Pagé, Sabrina Doblas, Octavia Bane, Stefanie Hectors, Iris Friedli, Bernard E. Van Beers, and John C. Waterton

36. Analysis Protocols for MRI Mapping of the Blood Oxygenation Sensitive Parameters T2* and T2 in the Kidney
João S. Periquito, Ludger Starke, Carlota M. Santos, Andreia C. Freitas, Nuno Loução, Pablo García Polo, Rita G. Nunes, Thoralf Niendorf, and Andreas Pohlmann

37. Analysis of Renal Diffusion Weighted Imaging (DWI) Using Apparent Diffusion Coefficient (ADC) and Intra Voxel Incoherent Motion (IVIM) Models
Neil Peter Jerome and João S. Periquito

38. Analysis Protocol for Dynamic Contrast Enhanced (DCE)-MRI of Renal Perfusion and Filtration 
Frank G. Zöllner, Walter Dastrù, Pietro Irrera, Dario Livio Longo, Kevin M. Bennett, Scott C. Beeman, G. Larry Bretthorst, and Joel R. Garbow

39. Quantitative Analysis of Renal Perfusion by Arterial Spin Labeling
Kai-Hsiang Chuang, Frank Kober, and Min-Chi Ku

40. Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST)-MRI
Hahnsung Kim, Yin Wu, Daisy Villano, Dario Livio Longo, Michael T. McMahon, and Phillip Zhe Sun

41. Analysis Protocol for Renal Sodium (23Na) MR Imaging
James T. Grist, Esben Søvsø Hansen, Frank G. Zöllner, and Christoffer Laustsen

42. Analysis Methods for Hyperpolarized Carbon (13C) MRI of the Kidney
Galen D. Reed, Natalie J. Korn, Christoffer Laustsen, and Cornelius von Morze

43. Data Preparation Protocol for Low Signal-to-Noise Ratio Fluorine-19 MRI
Ludger Starke, Thoralf Niendorf, and Sonia Waiczies

Subject Index List...

Blurb

This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and improve the reproducibility of renal imaging research. Chapters provide guidance for exploring, using and developing small animal renal MRI in your laboratory as a unique tool for advanced in vivo phenotyping, diagnostic imaging, and research into potential new therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Preclinical MRI of the Kidney: Methods and Protocols is a valuable resource and will be of importance to anyone interested in the preclinical aspect of renal and cardiorenal diseases in the fields of physiology, nephrology, radiology, and cardiology. 

This publication is based upon work from COST Action PARENCHIMA, supported by European Cooperation in Science and Technology (COST). COST (www.cost.eu) is a funding agency for research and innovation networks. COST Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility and standardization of renal MRI biomarkers.