Physiologically Based Pharmacokinetic (Pbpk) Modeling: Methods and Applications in Toxicology and Risk Assessment

ISBN-13: 9780128185964 / Angielski / Miękka / 2020 / 360 str.

Jeffrey Fisher; Jeffery Gearhart; Zhoumeng Lin

Spis treści

Foreword Melvin Andersen

Preface Jeffrey W. Fisher, Zhoumeng Lin and Jeffery M. Gearhart

1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topics Zhoumeng Lin and Jeffrey W. Fisher

2. Introduction to classical pharmacokinetics Shruti V. Kabadi and Zhoumeng Lin

3. Fundamentals of physiologically based pharmacokinetic modeling Jeff Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand and Zhoumeng Lin

4. Physiologically based pharmacokinetic modeling software C.E. Hack, A.Y. Efremenko, S.N. Pendse, C.A. Ellison, A. Najjar, N. Hewitt, A. Schepky and H.J. Clewell III

5. Chemical absorption and writing code for portals of entry Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr and Darshan Mehta

6. Physiologically based pharmacokinetic model: distribution processes Christopher Ruark

7. Metabolism and physiologically based pharmacokinetic models Jeffrey W. Fisher, Jerry L. Campbell Jr. and Zhoumeng Lin

8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breath Sami Haddad and Andy Nong

9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis Tammie R. Covington and Jeffery M. Gearhart

10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment Zhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou and Miao Li

11. Examples of physiologically based pharmacokinetic modeling applied to risk assessment Lisa M. Sweeney and Jeffery M. Gearhart

12. Physiologically based pharmacokinetic models to support modernized chemical safety assessment Miyoung Yoon